dc.contributor.author | Benito-León, J. | |
dc.contributor.author | Elan D., Louis | |
dc.contributor.author | Mato-Abad, Virginia | |
dc.contributor.author | Dydak, Ulrike | |
dc.contributor.author | Álvarez-Linera, Juan | |
dc.contributor.author | Hernández-Tamames, Juan Antonio | |
dc.contributor.author | Molina-Arjona, José Antonio | |
dc.contributor.author | Malpica, Norberto | |
dc.contributor.author | Matarazzo, Michele | |
dc.contributor.author | Romero Muñoz, Juan Pablo | |
dc.contributor.author | Sánchez-Ferro, Álvaro | |
dc.date.accessioned | 2016-10-19T11:18:00Z | |
dc.date.available | 2016-10-19T11:18:00Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1536-5964 | |
dc.identifier.uri | http://hdl.handle.net/10641/1241 | |
dc.description.abstract | The pathogenesis of orthostatic tremor (OT) remains unclear, although some evidence points to dysfunction in the brainstem or
cerebellum. We used single voxel proton magnetic resonance spectroscopy (1H-MRS) (3 T) to investigate whether neurochemical
changes underlie abnormal cerebellar or cortical function in OT. Fourteen OT patients and 14 healthy controls underwent 1H-MRS
studies with voxels placed in midparietal gray matter and cerebellum (vermis and central white matter). Spectral analysis
was analyzed using the software package LCModel (version 6.3). The absolute metabolite concentrations and ratios of total
N-acetylaspartate+N-acetylaspartyl glutamate (NAA), choline-containing compounds, myoinositol, and glutamate+glutamine to
creatine were calculated. In midparietal gray matter spectra, we found a significant decrease in the absolute concentration of NAA in
OT patients versus healthy controls (7.76±0.25 vs 8.11±0.45, P=0.017). A similar decrease in NAA was seen in the cerebellar
vermis (7.33±0.61 vs 8.55±1.54, P=0.014) and cerebellar white matter (8.54±0.79 vs 9.95±1.57, P=0.010). No differences in
the other metabolites or their ratios were observed. Reductions in both cerebral cortical and cerebellar NAA suggest that there is
neuronal damage or loss in OT, raising the intriguing question as to whether OT is a neurodegenerative disease. Along with clinical
history and electrophysio0logical examination, 1H-MRS could serve as a useful diagnostic aid for OT. | spa |
dc.language.iso | eng | spa |
dc.publisher | Medicine | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Case–control study | spa |
dc.subject | Cerebellum | spa |
dc.subject | Magnetic resonance imaging | spa |
dc.subject | Orthostatic tremor | spa |
dc.subject | Pathophysiology | spa |
dc.subject | Proton magnetic | spa |
dc.subject | Resonance spectroscopy | spa |
dc.title | In vivo neurometabolic profiling in orthostatic tremor | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 338 KB | spa |