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dc.contributor.authorFlores, África
dc.contributor.authorHerry, Cyril
dc.contributor.authorMaldonado, Rafael
dc.contributor.authorBerrendero, Fernando 
dc.date.accessioned2017-07-07T07:29:24Z
dc.date.available2017-07-07T07:29:24Z
dc.date.issued2017-04
dc.identifier.issn1469-5111
dc.identifier.urihttp://hdl.handle.net/10641/1315
dc.description.abstractBackground: Orexins are hypothalamic neuropeptides recently involved in the regulation of emotional memory. The basolateral amygdala, an area orchestrating fear memory processes, appears to be modulated by orexin transmission during fear extinction. However, the neuronal types within the basolateral amygdala involved in this modulation remain to be elucidated. Methods: We used retrograde tracing combined with immunofluorescence techniques in mice to identify basolateral amygdala projection neurons and cell subpopulations in this brain region influenced by orexin transmission during contextual fear extinction consolidation. Results: Treatment with the orexin-1 receptor antagonist SB334867 increased the activity of basolateral amygdala neurons projecting to infralimbic medial prefrontal cortex during fear extinction. GABAergic interneurons expressing calbindin, but not parvalbumin, were also activated by orexin-1 receptor antagonism in the basolateral amygdala. Conclusions: These data identify neuronal circuits and cell populations of the amygdala associated with the facilitation of fear extinction consolidation induced by the orexin-1 receptor antagonist SB334867.spa
dc.language.isoengspa
dc.publisherInternational Journal of Neuropsychopharmacologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectFear extinctionspa
dc.subjectOrexinspa
dc.subjectAmygdalaspa
dc.subjectRetrograde labelingspa
dc.subjectCalbindinspa
dc.titleFacilitation of Contextual Fear Extinction by Orexin-1 Receptor Antagonism Is Associated with the Activation of Specific Amygdala Cell Subpopulations.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1256 KBspa


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