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dc.contributor.authorGroult, Hugo
dc.contributor.authorGarcía Álvarez, Isabel
dc.contributor.authorRomero Ramírez, Lorenzo
dc.contributor.authorNieto Sampedro, Manuel
dc.contributor.authorHerranz, Fernando
dc.contributor.authorFernández Mayoralas, Alfonso
dc.contributor.authorRuiz Cabello, Jesús
dc.date.accessioned2018-11-19T11:28:44Z
dc.date.available2018-11-19T11:28:44Z
dc.date.issued2018
dc.identifier.issn2079-4991spa
dc.identifier.urihttp://hdl.handle.net/10641/1513
dc.description.abstractThe synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy.spa
dc.language.isoengspa
dc.publisherNanomayerialsspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectGlycosidespa
dc.subjectIron oxide nanoparticlesspa
dc.subjectNanomicellesspa
dc.subjectAntitumoralspa
dc.titleMicellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides.spa
dc.typearticlespa
dc.description.versionpost-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent1357 KBspa
dc.identifier.doi10.3390/nano8080567spa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España