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dc.contributor.authorBerrendero, Fernando 
dc.contributor.authorFlores, África
dc.contributor.authorRobledo, Patricia
dc.date.accessioned2018-11-20T13:03:06Z
dc.date.available2018-11-20T13:03:06Z
dc.date.issued2018
dc.identifier.issn0006-2952spa
dc.identifier.urihttp://hdl.handle.net/10641/1533
dc.description.abstractA growing body of evidence suggests the existence of biochemical and functional interactions between the endocannabinoid and orexin systems. Cannabinoid and orexin receptors have been shown to form heterodimers in agreement with the overlapping distribution of both receptors in several brain areas, and the activation of common intracellular signaling pathways, such as the MAP kinase cascade. The activation of orexin receptors induces the synthesis of the endocannabinoid 2-arachidonoyl glycerol suggesting that the endocannabinoid system participates in some physiological functions of orexins. Indeed, functional interactions between these two systems have been demonstrated in several behavioral responses including nociception, reward and food intake. The present review is focused on the latest developments in cannabinoid-orexin cross-modulation and the implications of this interesting interaction.spa
dc.language.isoengspa
dc.publisherBiochemical Pharmacologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectCannabinoidspa
dc.subjectFeedingspa
dc.subjectHeterodimersspa
dc.subjectNociceptionspa
dc.subjectOrexinspa
dc.titleWhen Orexins Meet Cannabinoids: Bidirectional Functional Interactions.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent455 KBspa
dc.identifier.doi10.1016/j.bcp.2018.08.040spa


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Atribución-NoComercial-SinDerivadas 3.0 España
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España