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dc.contributor.authorSaravia, Rocío
dc.contributor.authorTen Blanco, Marc
dc.contributor.authorJulià Hernández, Marina
dc.contributor.authorGagliano, Humberto
dc.contributor.authorAndero, Raül
dc.contributor.authorArmario, Antonio
dc.contributor.authorMaldonado, Rafael
dc.contributor.authorBerrendero, Fernando 
dc.date.accessioned2018-11-26T12:39:05Z
dc.date.available2018-11-26T12:39:05Z
dc.date.issued2018
dc.identifier.issn1873-7064spa
dc.identifier.urihttp://hdl.handle.net/10641/1540
dc.description.abstractΔ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid exposure in the adolescent period can also contribute to exacerbate behavioural deficits in adulthood. Here we investigate the effects of THC treatment as well as the consequences of concomitant THC and stress exposure during adolescence in the extinction of fear memory in adult mice. Adolescent mice treated with THC and exposed to stress exhibit impaired cued fear extinction in adulthood. However, no effect was observed in animals exposed to these two factors separately. Notably, resistance to fear extinction was associated with decreased neuronal activity in the basolateral amygdala (BLA) and the infralimbic prefrontal cortex, suggesting a long-term dysregulation of the fear circuit. These changes in neuronal activation were paralleled with structural plasticity alterations. Indeed, an increase of immature dendritic spines in pyramidal neurons of the BLA was revealed in mice simultaneously exposed to THC and stress. Corticosterone levels were also enhanced after the cued fear conditioning session in the same experimental group. These results show that an interaction between cannabis exposure and stress during adolescence may lead to long-term anxiety disorders characterized by the presence of pathological fear.spa
dc.language.isoengspa
dc.publisherNeuropharmacologyspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectΔ9-tetrahydrocannabinolspa
dc.subjectStressspa
dc.subjectAdolescencespa
dc.subjectFear extinctionspa
dc.subjectDendritic spinesspa
dc.subjectAmygdalaspa
dc.titleConcomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood.spa
dc.typearticlespa
dc.description.versionpre-printspa
dc.rights.accessRightsopenAccessspa
dc.description.extent312 KBspa
dc.identifier.doi10.1016/j.neuropharm.2018.11.016spa


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