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dc.contributor.authorSerrano, José Ignacio
dc.contributor.authorDel Castillo, María Dolores
dc.contributor.authorCortés, Verónica
dc.contributor.authorMendes, Nuno
dc.contributor.authorArroyo, Aída
dc.contributor.authorAndreo, Jorge
dc.contributor.authorRocón, Eduardo
dc.contributor.authorDel Valle, María
dc.contributor.authorHerreros, Jaime
dc.contributor.authorRomero Muñoz, Juan Pablo 
dc.date.accessioned2020-01-20T09:00:46Z
dc.date.available2020-01-20T09:00:46Z
dc.date.issued2018
dc.identifier.issn1662-4548spa
dc.identifier.urihttp://hdl.handle.net/10641/1822
dc.description.abstractObjectives: Characterizing pharmacological response in Parkinson’s Disease (PD) patients may be a challenge in early stages but gives valuable clues for diagnosis. Neurotropic drugs may modulate Electroencephalography (EEG) microstates (MS). We investigated EEG-MS default-mode network changes in response to dopaminergic stimulation in PD. Methods: Fourteen PD subjects in HY stage III or less were included, and twentyone healthy controls. All patients were receiving dopaminergic stimulation with levodopa or dopaminergic agonists. Resting EEG activity was recorded before the first daily PD medication dose and 1 h after drug intake resting EEG activity was again recorded. Time and frequency variables for each MS were calculated. Results: Parkinson’s disease subjects MS A duration decreases after levodopa intake, MS B appears more often than before levodopa intake. MS E was not present, but MS G was. There were no significant differences between control subjects and patients after medication intake. Conclusion: Clinical response to dopaminergic drugs in PD is characterized by clear changes in MS profile. Significance: This work demonstrates that there are clear EEG MS markers of PD dopaminergic stimulation state. The characterization of the disease and its response to dopaminergic medication may be of help for early therapeutic diagnosis.spa
dc.language.isoengspa
dc.publisherFrontiers in Neurosciencespa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectParkinson’s diseasespa
dc.subjectElectroencephalographyspa
dc.subjectMicrostatesspa
dc.subjectLevodopaspa
dc.subjectDiagnosisspa
dc.titleEEG Microstates Change in Response to Increase in Dopaminergic Stimulation in Typical Parkinson’s Disease Patients.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.description.extent606 KBspa
dc.identifier.doi10.3389/fnins.2018.00714spa
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fnins.2018.00714/fullspa


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Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 España