Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability.
Resumen: Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling.
This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling
induced by chronic hypertension. Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive
dronedarone (100mg/kg) or vehicle. Age-matched maleWistar-Kyoto rats served as controls. After 14 days of treatment, we studied
the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis. Nitric oxide (NO) in plasma was
analyzed. In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional
area, and collagen volume density, as was expected in the experimental model. Dronedarone induced a significant decrease in wall
width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR. The values obtained in
SHR-D were similar in the WKY control group. We found significantly higher NO levels in plasma in SHR-D than in untreated
SHR. Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased
nitric oxide bioavailability.
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- MEDICINA [789]