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dc.contributor.authorSánchez Cuesta, Francisco José
dc.contributor.authorArroyo Ferrer, Aída
dc.contributor.authorGonzález Zamorano, Yeray
dc.contributor.authorVourvopoulos, Athanasios
dc.contributor.authorBermúdez i Badia, Sergi
dc.contributor.authorFiguereido, Patricia
dc.contributor.authorSerrano, José Ignacio
dc.contributor.authorRomero Muñoz, Juan Pablo
dc.description.abstractBackground and Objectives: The motor sequelae after a stroke are frequently persistent and cause a high degree of disability. Cortical ischemic or hemorrhagic strokes affecting the corticospinal pathways are known to cause a reduction of cortical excitability in the lesioned area not only for the local connectivity impairment but also due to a contralateral hemisphere inhibitory action. Non-invasive brain stimulation using high frequency repetitive magnetic transcranial stimulation (rTMS) over the lesioned hemisphere and contralateral cortical inhibition using low-frequency rTMS have been shown to increase the excitability of the lesioned hemisphere. Mental representation techniques, neurofeedback, and virtual reality have also been shown to increase cortical excitability and complement conventional rehabilitation. Materials and Methods: We aim to carry out a single-blind, randomized, controlled trial aiming to study the efficacy of immersive multimodal Brain–Computer Interfacing-Virtual Reality (BCI-VR) training after bilateral neuromodulation with rTMS on upper limb motor recovery after subacute stroke (>3 months) compared to neuromodulation combined with conventional motor imagery tasks. This study will include 42 subjects in a randomized controlled trial design. The main expected outcomes are changes in the Motricity Index of the Arm (MI), dynamometry of the upper limb, score according to Fugl-Meyer for upper limb (FMA-UE), and changes in the Stroke Impact Scale (SIS). The evaluation will be carried out before the intervention, after each intervention and 15 days after the last session. Conclusions: This trial will show the additive value of VR immersive motor imagery as an adjuvant therapy combined with a known effective neuromodulation approach opening new perspectives for clinical rehabilitation
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.subjectRepetitive transcranial magnetic stimulationspa
dc.subjectBCI-VR trainingspa
dc.subjectMotor skillsspa
dc.subjectUpper limbspa
dc.titleClinical Effects of Immersive Multimodal BCI-VR Training after Bilateral Neuromodulation with rTMS on Upper Limb Motor Recovery after Stroke. A Study Protocol for a Randomized Controlled
dc.typejournal articlespa
dc.rights.accessRightsopen accessspa
dc.description.extent966 KBspa

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Atribución-NoComercial-SinDerivadas 3.0 España
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