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dc.contributor.author
dc.contributor.authorLorenzini, Massimiliano
dc.contributor.authorCicerchia, Marcos
dc.contributor.authorOchoa, Juan Pablo
dc.contributor.authorHey, Thomas Morris
dc.contributor.authorSabater Molina, Maria
dc.contributor.authorRestrepo-Cordoba, Maria Alejandra
dc.contributor.authorDal Ferro, Matteo
dc.contributor.authorStolfo, Davide
dc.contributor.authorJohnson, Renee
dc.contributor.authorLarrañaga-Moreira, José M.
dc.contributor.authorRobles-Mezcua, Ainhoa
dc.contributor.authorRodriguez-Palomares, Jose F.
dc.contributor.authorCasas, Guillem
dc.contributor.authorPeña-Peña, Maria Luisa
dc.contributor.authorLopes, Luis Rocha
dc.contributor.authorGallego-Delgado, Maria
dc.contributor.authorFranaszczyk, Maria
dc.contributor.authorLaucey, Gemma
dc.contributor.authorRangel-Sousa, Diego
dc.contributor.authorBasurte, Mayte
dc.contributor.authorPalomino-Doza, Julian
dc.contributor.authorVillacorta, Eduardo
dc.contributor.authorBilinska, Zofia
dc.contributor.authorLimeres Freire, Javier
dc.contributor.authorGarcia Pinilla, José M. José M.
dc.contributor.authorBarriales-Villa, Roberto
dc.contributor.authorFatkin, Diane
dc.contributor.authorSinagra, Gianfranco
dc.contributor.authorGarcía Pavía, Pablo 
dc.contributor.authorGimeno, Juan R.
dc.contributor.authorMogensen, Jens
dc.contributor.authorMonserrat, Lorenzo
dc.contributor.authorElliott, Perry M.
dc.contributor.authorAkhtar, Mohammed
dc.date.accessioned2021-08-27T08:54:26Z
dc.date.available2021-08-27T08:54:26Z
dc.date.issued2020
dc.identifier.issn1941-3289spa
dc.identifier.urihttp://hdl.handle.net/10641/2400
dc.description.abstractBackground: Truncating variants in the TTN gene (TTNtv) are the commonest cause of heritable dilated cardiomyopathy. This study aimed to study the phenotypes and outcomes of TTNtv carriers. Methods: Five hundred thirty-seven individuals (61% men; 317 probands) with TTNtv were recruited in 14 centers (372 [69%] with baseline left ventricular systolic dysfunction [LVSD]). Baseline and longitudinal clinical data were obtained. The primary end point was a composite of malignant ventricular arrhythmia and end-stage heart failure. The secondary end point was left ventricular reverse remodeling (left ventricular ejection fraction increase by ≥10% or normalization to ≥50%). Results: Median follow-up was 49 (18–105) months. Men developed LVSD more frequently and earlier than women (45±14 versus 49±16 years, respectively; P=0.04). By final evaluation, 31%, 45%, and 56% had atrial fibrillation, frequent ventricular ectopy, and nonsustained ventricular tachycardia, respectively. Seventy-six (14.2%) individuals reached the primary end point (52 [68%] end-stage heart failure events, 24 [32%] malignant ventricular arrhythmia events). Malignant ventricular arrhythmia end points most commonly occurred in patients with severe LVSD. Male sex (hazard ratio, 1.89 [95% CI, 1.04–3.44]; P=0.04) and left ventricular ejection fraction (per 10% decrement from left ventricular ejection fraction, 50%; hazard ratio, 1.63 [95% CI, 1.30–2.04]; P<0.001) were independent predictors of the primary end point. Two hundred seven of 300 (69%) patients with LVSD had evidence of left ventricular reverse remodeling. In a subgroup of 29 of 74 (39%) patients with initial left ventricular reverse remodeling, there was a subsequent left ventricular ejection fraction decrement. TTNtv location was not associated with statistically significant differences in baseline clinical characteristics, left ventricular reverse remodeling, or outcomes on multivariable analysis (P=0.07). Conclusions: TTNtv is characterized by frequent arrhythmia, but malignant ventricular arrhythmias are most commonly associated with severe LVSD. Male sex and LVSD are independent predictors of outcomes. Mutation location does not impact clinical phenotype or outcomes.spa
dc.language.isoengspa
dc.publisherCirculation: Heart Failurespa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTitinspa
dc.subjectDilated Cardiomyopathyspa
dc.subjectSexspa
dc.subjectLV reverse remodellingspa
dc.subjectHeart Failurespa
dc.titleClinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN Gene.spa
dc.typejournal articlespa
dc.type.hasVersionSMURspa
dc.rights.accessRightsopen accessspa
dc.description.extent1,66 MBspa
dc.identifier.doi10.1161/CIRCHEARTFAILURE.119.006832spa
dc.relation.publisherversionhttps://www.ahajournals.org/doi/10.1161/CIRCHEARTFAILURE.119.006832spa


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