dc.contributor.author | Campillo, Noelia | |
dc.contributor.author | Rosa Oliveira, Vinicius | |
dc.contributor.author | Kelly da Palma, Renata | |
dc.date.accessioned | 2022-01-31T12:59:52Z | |
dc.date.available | 2022-01-31T12:59:52Z | |
dc.date.issued | 2021 | |
dc.identifier.issn | 2227-9040 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2753 | |
dc.description.abstract | Respiratory diseases are top-ranked causes of deaths and disabilities around the world, making new approaches to the treatment necessary. In recent years, lung-on-a-chip platforms have emerged as a potential candidate to replace animal experiments because they can successfully simulate human physiology. In this review, we discuss the main respiratory diseases and their pathophysiology, how to model a lung microenvironment, and how to translate it to clinical applications. Furthermore, we propose a novel alveolus lung-on-a-chip platform, based on all currently available methodologies. This review provides solutions and new ideas to improve the alveolar lung-on-a-chip platform. Finally, we provided evidence that approaches such as 3D printing, organ-a-chip devices and organoids can be used in combination, and some challenges could be overcome. | spa |
dc.language.iso | eng | spa |
dc.publisher | Chemosensor | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Lung disease | spa |
dc.subject | Microfluidic | spa |
dc.subject | Organ-on-a-chip | spa |
dc.title | Alveolus Lung-on-a-Chip Platform: A Proposal. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 1239 KB | spa |
dc.identifier.doi | 10.3390/chemosensors9090248 | spa |
dc.relation.publisherversion | https://www.mdpi.com/2227-9040/9/9/248 | spa |