Chronodisruption and Ambulatory Circadian Monitoring in Cancer Patients: Beyond the Body Clock.
Autor: Almaida‑Pagan, Pedro F.; Torrente, María; Campos, Manuel; Provencio, Mariano; Madrid, Juan Antonio; Franco, Fabio; Rodríguez Morilla, Beatriz; Cantos, Blanca; Sousa, Pedro A.; Martínez Madrid, María José; Pimentao, Joao; Rol, María Ángeles
Resumen: Purpose of Review Circadian rhythms impose daily rhythms a remarkable variety of metabolic and physiological functions,
such as cell proliferation, infammation, and DNA damage response. Accumulating epidemiological and genetic evidence
indicates that circadian rhythms’ disruption may be linked to cancer. The integration of circadian biology into cancer research
may ofer new options for increasing cancer treatment efectiveness and would encompass the prevention, diagnosis, and
treatment of this disease.
Recent Findings In recent years, there has been a signifcant development and use of multi-modal sensors to monitor physical
activity, sleep, and circadian rhythms, allowing, for the very frst time, scaling accurate sleep monitoring to epidemiological
research linking sleep patterns to disease, and wellness applications providing new potential applications.
Summary This review highlights the role of circadian clock in tumorigenesis, cancer hallmarks and introduces the stateof-the-art in sleep-monitoring technologies, discussing the eventual application of insights in clinical settings and cancer
research.
Identificador universal: https://hdl.handle.net/10641/3245
Fecha: 2022
Ficheros en el ítem
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
s11912-021-01158-z.pdf | 1.051Mb | Ver/ |
Este ítem aparece en la(s) siguiente(s) colección(ones)
- MEDICINA [789]