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Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis.

dc.contributor.authorLarrodera, Pilar
dc.contributor.authorCornet, María E.
dc.contributor.authorDíaz Meco, María T.
dc.contributor.authorHenrik Guddal, Per
dc.contributor.authorJohansen, Terje
dc.contributor.authorLópez Barahona, Mónica 
dc.contributor.authorDiaz-Laviada, Inés
dc.contributor.authorMoscat, Jorge
dc.date.accessioned2024-01-23T11:54:36Z
dc.date.available2024-01-23T11:54:36Z
dc.date.issued1990
dc.identifier.issn0092-8674spa
dc.identifier.urihttps://hdl.handle.net/10641/3800
dc.description.abstractRecent evidence suggests the involvement of phosphatidylcholine (PC) hydrolysis both in the control of normal cell growth and in transformation. We show here that the simple exogenous addition of Bacillus cereus PC-hydrolyzing phospholipase C (PC-PLC) is sufficient to elicit a potent mitogenic response in Swiss 3T3 fibroblasts by a mechanism that is independent of protein kinase C. Our results on the additivity and synergism between B. cereus PC-PLC, PDGF, and insulin in the mitogenic response indicate that this novel phospholipid degradative pathway may be important in the mitogenic signaling cascade activated by PDGF.spa
dc.language.isoengspa
dc.publisherCellspa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titlePhospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dc.rights.accessRightsopen accessspa
dc.identifier.doi10.1016/0092-8674(90)90074-Ospa
dc.relation.publisherversionhttps://www.cell.com/cell/pdf/0092-8674(90)90074-O.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2F009286749090074O%3Fshowall%3Dtruespa


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