dc.contributor.author | Elliott, Perry | |
dc.contributor.author | Gundapaneni, Balarama | |
dc.contributor.author | B. Sultan, Marla | |
dc.contributor.author | Ines, Monica | |
dc.contributor.author | García Pavía, Pablo | |
dc.date.accessioned | 2024-02-23T09:20:58Z | |
dc.date.available | 2024-02-23T09:20:58Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 1388-9842 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/4085 | |
dc.description.abstract | Aim
The value of disease-modifying therapies (such as tafamidis) in patients with transthyretin amyloid cardiomyopathy (ATTR-CM) and severe heart failure symptoms has been debated. This study assessed long-term all-cause survival in patients with New York Heart Association (NYHA) class III symptoms in the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT) long-term extension (LTE) study.
Methods and results
At the baseline of ATTR-ACT, 55/176 (31.3%) patients receiving tafamidis 80 mg and 63/177 (35.6%) receiving placebo had NYHA class III symptoms. After 30 months of treatment, patients could join an ongoing LTE study to receive open-label tafamidis. In an interim analysis of the LTE study (August 2021), all-cause mortality was lower among patients with NYHA class III symptoms who received continuous tafamidis in ATTR-ACT and the LTE study (hazard ratio 0.64; 95% confidence interval 0.41–0.99; median follow-up: 60 months), as compared with those who received placebo in ATTR-ACT and tafamidis in the LTE study (median follow-up: 56 months). Similar findings were observed in patients with NYHA class I/II symptoms at baseline (0.50; 0.35–0.73; tafamidis 80 mg n = 121; placebo n = 114; median follow-up of 61 and 60 months, respectively).
Conclusion
We observed reduced all-cause mortality with continuous tafamidis treatment compared with delayed tafamidis treatment (placebo then tafamidis) in patients with NYHA class III symptoms at baseline over a median follow-up of ∼5 years. These findings demonstrate the value of tafamidis treatment in patients with ATTR-CM and severe heart failure symptoms, and emphasize the importance of early treatment. | spa |
dc.language.iso | eng | spa |
dc.publisher | European Journal of Heart Failure | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Amyloidosis | spa |
dc.subject | Survival rate | spa |
dc.subject | Prognosis | spa |
dc.title | Improved long-term survival with tafamidis treatment in patients with transthyretin amyloid cardiomyopathy and severe heart failure symptoms. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 575 KB | spa |
dc.identifier.doi | 10.1002/ejhf.2974 | spa |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2974 | spa |