Browsing by Author "Palacios, Beatriz"
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Item Activation of amino acid metabolic program in cardiac HIF1-alpha-deficient mice.(iScience, 2021) Menéndez Montes, Iván; Escobar, Beatriz; Gómez, Manuel J.; Albendea Gómez, Teresa; Palacios, Beatriz; Bonzon Kulichenko, Elena; Izquierdo García, José Luis; Alonso, Ana Vanessa; Ferrarini, Alessia; Jiménez Borreguero, Luis Jesús; Ruiz Cabello, Jesús; Vázquez, Jesús; Martín Puig, SilviaHIF1-alpha expression defines metabolic compartments in the developing heart, promoting glycolytic program in the compact myocardium and mitochondrial enrichment in the trabeculae. Nonetheless, its role in cardiogenesis is debated. To assess the importance of HIF1-alpha during heart development and the influence of glycolysis in ventricular chamber formation, herein we generated conditional knockout models of Hif1a in Nkx2.5 cardiac progenitors and cardiomyocytes. Deletion of Hif1a impairs embryonic glycolysis without influencing cardiomyocyte proliferation and results in increased mitochondrial number and transient activation of amino acid catabolism together with HIF2a and ATF4 upregulation by E12.5. Hif1a mutants display normal fatty acid oxidation program and do not show cardiac dysfunction in the adulthood. Our results demonstrate that cardiac HIF1 signaling and glycolysis are dispensable for mouse heart development and reveal the metabolic flexibility of the embryonic myocardium to consume amino acids, raising the potential use of alternative metabolic substrates as therapeutic interventions during ischemic events.Item Effects of the COVID-19 pandemic on perinatal mental health in Spain: Positive and negative outcomes.(Women and Birth, 2022) Chaves Vélez, Covadonga; Marchena Giráldez, Carlos Alberto; Palacios, Beatriz; Salgado, Alfonso; Duque, AlmudenaBackground Previous studies have shown that perinatal distress has a negative influence on pregnancy outcome and the physiological development of the baby. Objective The aim of this study was to describe the effects of the COVID-19 pandemic on maternal perinatal mental health in Spain. Methods Seven hundred and twenty-four women (N = 450 pregnancy, N = 274 postpartum) were recruited online during the pandemic. The Edinburgh Postnatal Depression Scale, the Positive and Negative Affect Schedule, and the Satisfaction With Life Scale were administered. Variables related to sociodemographic information, the COVID-19 pandemic, and perinatal care were also assessed. Findings The results showed that 58% of women reported depressive symptoms. Moreover, 51% of women reported anxiety symptoms. On the other hand, a regression analysis for life satisfaction showed that besides the perception about their own health, marital status or being a health practitioner were also significant predictors during pregnancy. However, perception about baby’s health and sleep, perception about their own health, and marital status were significant predictors of life satisfaction during the postpartum stage. Discussion Women assessed during the COVID-19 pandemic reported high rates of psychological distress. Conclusion These results highlight the need of clinical support during this period. Knowing the routes to both distress and well-being may help maternity services to effectively cope with the pandemic.