Transcriptional analysis of the dachsous gene uncovers novel isoforms expressed during development in Drosophila.
dc.contributor.author | Revilla Yates, Eva | |
dc.contributor.author | Varas, Laura | |
dc.contributor.author | Sierra Isturiz, Javier | |
dc.contributor.author | Rodríguez, Isabel | |
dc.date.accessioned | 2019-10-19T09:04:32Z | |
dc.date.available | 2019-10-19T09:04:32Z | |
dc.date.issued | 2015 | |
dc.description.abstract | The Drosophila cadherin-related protein Dachsous (Ds) plays a prominent role in planar cell polarity (PCP) and growth. The regulation of these two processes is based on the interaction between Ds and Fat proteins, generating an intracellular response required for tissue polarization and modulation of Hippo pathway activity. Here we have performed a comprehensive molecular study of the ds gene during larval development that has shown an unexpected complexity in its transcriptional regulation and revealed the expression of hitherto unsuspected transcripts. Also, knockdown of several isoforms provides new evidence on the importance of the cytoplasmic domain in the mechanism of action of Ds during development. | spa |
dc.description.extent | 1385 KB | spa |
dc.identifier.doi | 10.1016/j.febslet.2015.10.012 | spa |
dc.identifier.issn | 0014-5793 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/1698 | |
dc.language.iso | eng | spa |
dc.publisher | FEBS Letters | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Dachsous transcript | spa |
dc.subject | Drosophila | spa |
dc.subject | DsIntra isoform | spa |
dc.subject | Planar cell polarity | spa |
dc.title | Transcriptional analysis of the dachsous gene uncovers novel isoforms expressed during development in Drosophila. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | be7339a7-8121-44b8-bccb-eeef5135428c | |
relation.isAuthorOfPublication.latestForDiscovery | be7339a7-8121-44b8-bccb-eeef5135428c |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- FEBSLETTERS.pdf
- Size:
- 1.35 MB
- Format:
- Adobe Portable Document Format
- Description: