Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19.
dc.contributor.author | Velázquez, Sara | |
dc.contributor.author | Madurga Lacalle, Rodrigo | |
dc.contributor.author | Castellano, José María | |
dc.contributor.author | Rodríguez Pascual, Jesús | |
dc.contributor.author | Ruiz de Aguiar Diaz Obregon, Santiago | |
dc.contributor.author | Jimeno, Sara | |
dc.contributor.author | Montero, Juan Ignacio | |
dc.contributor.author | Ventura Wichner, Paula Sol | |
dc.contributor.author | López Escobar, Alejandro | |
dc.date.accessioned | 2022-02-15T11:21:30Z | |
dc.date.available | 2022-02-15T11:21:30Z | |
dc.date.issued | 2021 | |
dc.description.abstract | Background The vast impact of COVID-19 call for the identification of clinical parameter that can help predict a torpid evolution. Among these, endothelial injury has been proposed as one of the main pathophysiological mechanisms underlying the disease, promoting a hyperinflammatory and prothrombotic state leading to worse clinical outcomes. Leukocytes and platelets play a key role in inflammation and thrombogenesis, hence the objective of the current study was to study whether neutrophil-to-lymphocyte ratio (NLR), platelets-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) as well as the new parameter neutrophil-to-platelet ratio (NPR), could help identify patients who at risk of admission at Intensive Care Units. Methods A retrospective observational study was performed at HM Hospitales including electronic health records from 2245 patients admitted due to COVID-19 from March 1 to June 10, 2020. Patients were divided into two groups, admitted at ICU or not. Results Patients who were admitted at the ICU had significantly higher values in all hemogram-derived ratios at the moment of hospital admission compared to those who did not need ICU admission. Specifically, we found significant differences in NLR (6.9 [4–11.7] vs 4.1 [2.6–7.6], p < 0.0001), PLR (2 [1.4–3.3] vs 1.9 [1.3–2.9], p = 0.023), NPR (3 [2.1–4.2] vs 2.3 [1.6–3.2], p < 0.0001) and SII (13 [6.5–25.7] vs 9 [4.9–17.5], p < 0.0001) compared to those who did not require ICU admission. After multivariable logistic regression models, NPR was the hemogram-derived ratio with the highest predictive value of ICU admission, (OR 1.11 (95% CI: 0.98–1.22, p = 0.055). Conclusions Simple, hemogram-derived ratios obtained from early hemogram at hospital admission, especially the novelty NPR, have shown to be useful predictors of risk of ICU admission in patients hospitalized due to COVID-19. | spa |
dc.description.extent | 997 KB | spa |
dc.identifier.doi | 10.1186/s12873-021-00480-w | spa |
dc.identifier.issn | 1471-227X | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2815 | |
dc.language.iso | eng | spa |
dc.relation.publisherversion | BMC Emergency Medicine | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | COVID-19 | spa |
dc.subject | Hemogram | spa |
dc.subject | Hemogram-derived ratio | spa |
dc.subject | Neutrophil-to-platelet ratio | spa |
dc.subject | Neutrophil-to-lymphocyte ratio | spa |
dc.subject | ICU admission | spa |
dc.title | Hemogram-derived ratios as prognostic markers of ICU admission in COVID-19. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dspace.entity.type | Publication |
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