THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice.
dc.contributor.author | Flores, África | |
dc.contributor.author | Maldonado, Rafael | |
dc.contributor.author | Berrendero, Fernando | |
dc.date.accessioned | 2020-02-05T11:56:09Z | |
dc.date.available | 2020-02-05T11:56:09Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Rationale: Cannabis use is typically initiated during adolescence, and different studies suggest that adolescent cannabinoid exposure may increase the risk for drug addiction in adulthood. Objectives: This study investigated the effects of adolescent exposure to the main psychoactive component of cannabis, Δ9-tetrahydrocannabinol (THC), in the reinforcing properties of nicotine in adult male mice. Possible alterations in relapse to nicotine-seeking behaviour in adult animals due to THC adolescent exposure were also evaluated. Methods: Adolescent mice were exposed to escalating doses of THC from PND35 to PND49. When mice reached adulthood (PND70), surgical procedures were applied for further behavioural evaluation. Nicotine self-administration sessions were conducted consecutively for 10 days. Following extinction, mice were tested for cue- and stress-induced reinstatement of nicotine-seeking behaviour. Results: Adolescent THC treatment did not modify acquisition and extinction of nicotine self-administration in adulthood. Moreover, THC exposure did not alter relapse to nicotine seeking induced by stress or nicotine-associated cues. Conclusions: These results suggest that a history of exposure to THC during adolescence under these particular conditions does not modify the reinforcing effects and seeking behaviour of nicotine in the adult period. | spa |
dc.description.extent | 256 KB | spa |
dc.identifier.doi | 10.1007/s00213-019-05416-8 | spa |
dc.identifier.issn | 0033-3158 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/1846 | |
dc.language.iso | eng | spa |
dc.publisher | Psychopharmacology | spa |
dc.relation.publisherversion | https://link.springer.com/article/10.1007%2Fs00213-019-05416-8 | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Adolescence | spa |
dc.subject | Mice | spa |
dc.subject | Nicotine | spa |
dc.subject | Relapse | spa |
dc.subject | Reward | spa |
dc.subject | Δ9-tetrahydrocannabinol | spa |
dc.title | THC exposure during adolescence does not modify nicotine reinforcing effects and relapse in adult male mice. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | e1da9b15-03d3-4ea4-8e9f-894db83cf816 | |
relation.isAuthorOfPublication.latestForDiscovery | e1da9b15-03d3-4ea4-8e9f-894db83cf816 |
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