Effect of ACTN3 R577X Genotype on Injury Epidemiology in Elite Endurance Runners´.
dc.contributor.author | Gutiérrez Hellín, Jorge | |
dc.contributor.author | Baltazar Martins, Gabriel | |
dc.contributor.author | Aguilar Navarro, Millán | |
dc.contributor.author | Oliván, Jesús | |
dc.contributor.author | Del Coso, Juan | |
dc.date.accessioned | 2021-01-29T09:57:51Z | |
dc.date.available | 2021-01-29T09:57:51Z | |
dc.date.issued | 2021 | |
dc.description.abstract | The p.R577X polymorphism (rs1815739) in the ACTN3 gene causes individuals with the ACTN3 XX genotype to be deficient in functional α-actinin-3. Previous investigations have found that XX athletes are more prone to suffer non-contact muscle injuries. This investigation aimed to determine the influence of the ACTN3 R577X polymorphism in the injury epidemiology of elite endurance athletes. Using a cross-sectional experiment, the epidemiology of running-related injuries was recorded for one season in a group of 89 Spanish elite endurance runners. ACTN3 R577X genotype was obtained for each athlete using genomic DNA samples. From the study sample, 42.7% of athletes had the RR genotype, 39.3% had the RX genotype, and 18.0% had the XX genotype. A total of 96 injuries were recorded in 57 athletes. Injury incidence was higher in RR runners (3.2 injuries/1000 h of running) than in RX (2.0 injuries/1000 h) and XX (2.2 injuries/1000 h; p = 0.030) runners. RR runners had a higher proportion of injuries located in the Achilles tendon, RX runners had a higher proportion of injuries located in the knee, and XX runners had a higher proportion of injuries located in the groin (p = 0.025). The ACTN3 genotype did not affect the mode of onset, the severity, or the type of injury. The ACTN3 genotype slightly affected the injury epidemiology of elite endurance athletes with a higher injury rate in RR athletes and differences in injury location. However, elite ACTN3 XX endurance runners were not more prone to muscle-type injuries. | spa |
dc.description.extent | 248 KB | spa |
dc.identifier.doi | 10.3390/genes12010076 | spa |
dc.identifier.issn | 2073-4425 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2202 | |
dc.language.iso | eng | spa |
dc.publisher | Genes | spa |
dc.relation.publisherversion | https://www.mdpi.com/2073-4425/12/1/76 | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Athletic performance | spa |
dc.subject | Exercise-related injury | spa |
dc.subject | Single nucleotide polymorphism | spa |
dc.subject | Track and field athlete | spa |
dc.title | Effect of ACTN3 R577X Genotype on Injury Epidemiology in Elite Endurance Runners´. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 1cccb91f-5305-4dcf-aa87-7e567976cc29 | |
relation.isAuthorOfPublication | 1263b63b-00bc-48a9-add2-dbfbdf3b4e6c | |
relation.isAuthorOfPublication.latestForDiscovery | 1cccb91f-5305-4dcf-aa87-7e567976cc29 |
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