the THAOS Investigators2026-01-282026-01-282024-08the THAOS Investigators 2024, 'Age- and Sex-Related Differences in Patients With Wild-Type Transthyretin Amyloidosis : Insights From THAOS', JACC: Advances, vol. 3, no. 8, 101086. https://doi.org/10.1016/j.jacadv.2024.1010862772-963XPubMedCentral: PMC11299582https://hdl.handle.net/10641/7727Publisher Copyright: © 2024 The AuthorsBackground: Wild-type transthyretin amyloidosis (ATTRwt amyloidosis) is primarily diagnosed in elderly men but diagnoses in younger patients and women have recently increased. Objectives: The purpose of this study was to examine age- and sex-related differences in patients with ATTRwt amyloidosis enrolled in the THAOS (Transthyretin Amyloidosis Outcomes Survey). Methods: THAOS was a global, longitudinal, observational survey of patients with transthyretin amyloidosis, including both hereditary and wild-type disease, and asymptomatic carriers of pathogenic transthyretin gene variants. Patient characteristics at enrollment were analyzed by age at enrollment and sex (data cutoff date: August 1, 2022). Results: Of 1,251 patients with ATTRwt amyloidosis, 13.7%, 49.1%, 34.5%, and 2.8% were aged <70 years, 70 to 79 years, 80 to 89 years, and ≥90 years, respectively. The proportion of women increased with age, from 4.1% in patients aged <70 years to 14.3% in patients aged ≥90 years. In the respective age groups, median time from symptom onset to diagnosis overall (male, female) was 1.7 (1.3, 5.2), 2.0 (2.0, 2.2), 1.8 (1.9, 0.8), and 0.7 (0.6, 2.5) years. A Karnofsky Performance Status score ≤70 was observed in 17.1%, 30.1%, 46.1%, and 44.4% of patients aged <70 years, 70 to 79 years, 80 to 89 years, and ≥90 years, respectively. Conclusions: In this THAOS analysis of patients with ATTRwt amyloidosis, patients were diagnosed an average of 2 years after symptom onset, with the greatest diagnostic delay in women aged <70 years at 5 years. Patients were predominantly men, but the proportion of women increased with age. A substantial proportion of patients had significant functional impairment regardless of age.850733enginfo:eu-repo/semantics/openAccessageamyloidcardiomyopathysex differencesCardiology and Cardiovascular MedicineJournal ArticleYesyes/dk/atira/pure/researchoutput/researchoutputtypes/contributiontojournal/article10.1016/j.jacadv.2024.101086https://www.scopus.com/pages/publications/85197778480https://www.scopus.com/pages/publications/85197778480#tab=citedBy