García-Magro, NuriaGarcía-Magro, NuriaMesa-Lombardo, AlbertoNuñez, Ángel2025-12-192025-12-192025-09García-Magro, N, Mesa-Lombardo, A & Nuñez, Á 2025, 'Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity : Entrainment of Metabolic and Brain Functions', Cells, vol. 14, no. 17, 1325. https://doi.org/10.3390/cells141713252073-4409PubMedCentral: PMC12428638https://hdl.handle.net/10641/6789Publisher Copyright: © 2025 by the authors.Insulin-like growth factor I (IGF-I) is a neurotrophic factor that regulates neurogenesis, synaptogenesis, and neuronal survival. It also enhances neuronal activity and facilitates synaptic plasticity. Additionally, IGF-I plays a critical role in the regulation of metabolism in mammals. Emerging evidence indicates that IGF-I modulates sleep architecture. The circadian integration of metabolic and neuronal systems serves to optimize energy utilization across the light/dark cycle. Current data suggest that IGF-I may be a key mediator of this integration, promoting brain activity during wakefulness, a state that coincides with increased metabolic demand. In this review, we summarize recent findings on the interplay between metabolism, IGF-I, and brain activity.758531enghttp://creativecommons.org/licenses/by-nc-nd/4.0/IGF-Icholinergic neuronscircadian rhythmselectrocorticogramgrowth hormoneorexinergic neuronssynaptic plasticityGeneral Biochemistry, Genetics and Molecular BiologyJournal ArticleReviewYesyesreview articleopen access10.3390/cells14171325https://www.scopus.com/pages/publications/105015894613https://www.scopus.com/pages/publications/105015894613#tab=citedBy