Fernández-Barat, LaiaMotos, AnaCanseco-Ribas, JoanGabarrús, AlbertLópez-Aladid, RubenAlvaro-Meca, AlejandroCeccato, AdriánGarcía, NadiaFerrer, MiquelBattaglini, DeniseÁvarez-Napagao, SergioGarcía-Gasulla, DarioFerrer, Ricardde Gonzalo-Calvo, DavidLorente, José ÁngelMenéndez, RosarioPeñuelas, OscarRiera, JordiRodríguez, AlejandroAmaya Villar, RosarioAñón, José M.Balan Mariño, AnaBarberà, CarmeBarberán, JoséBlandino Ortiz, AaronBoado, Maria VictoriaBofill, NeusBustamante-Munguira, ElenaCaballero, JesúsCantón-Bulnes, María LuisaCarbajales Pérez, CristinaCarbonell, NievesCatalán-González, Mercedesdel Carmen de la Torre, MariaDíaz, EmiliEstella, ÁngelFigueras, Albertde Frutos, RaulFranco, NievesGalbán, CristóbalGallego, ElenaGarcía Garmendia, José LuisGonzález, JessicaGómez, José M.Gumucio-Sanguino, Víctor D.Huerta, ArturoJorge García, Ruth NoemíLoza-Vázquez, AnaMarin-Corral, JudithMartin Delgado, María CruzMartínez de la Gándara, AmaliaMartínez Varela, IgnacioAlbaiceta, Guillermo M.Nieto, MaitePeñasco, YhivianPérez-Bastida, LeirePérez-García, FelipePozo-Laderas, Juan CarlosRicart, PilarSagredo, VíctorSánchez-Miralles, ÁngelSancho Chinesta, SusanaSocias, LorenzoSolé-Violan, JordiSuarez-Sipmann, FernandoTamayo Lomas, LuisTrenado, JoséÚbeda, AlejandroJorge Valdivia, LuisVidal, PabloBermejo-Martin, JesúsBarbé, FerranTorres, Antoni2025-12-182025-12-182025-09Fernández-Barat, L, Motos, A, Canseco-Ribas, J, Gabarrús, A, López-Aladid, R, Alvaro-Meca, A, Ceccato, A, García, N, Ferrer, M, Battaglini, D, Ávarez-Napagao, S, García-Gasulla, D, Ferrer, R, de Gonzalo-Calvo, D, Lorente, J Á, Menéndez, R, Peñuelas, O, Riera, J, Rodríguez, A, Amaya Villar, R, Añón, J M, Balan Mariño, A, Barberà, C, Barberán, J, Blandino Ortiz, A, Boado, M V, Bofill, N, Bustamante-Munguira, E, Caballero, J, Cantón-Bulnes, M L, Carbajales Pérez, C, Carbonell, N, Catalán-González, M, del Carmen de la Torre, M, Díaz, E, Estella, Á, Figueras, A, de Frutos, R, Franco, N, Galbán, C, Gallego, E, García Garmendia, J L, González, J, Gómez, J M, Gumucio-Sanguino, V D, Huerta, A, Jorge García, R N, Loza-Vázquez, A, Marin-Corral, J, Martin Delgado, M C, Martínez de la Gándara, A, Martínez Varela, I, Albaiceta, G M, Nieto, M, Peñasco, Y, Pérez-Bastida, L, Pérez-García, F, Pozo-Laderas, J C, Ricart, P, Sagredo, V, Sánchez-Miralles, Á, Sancho Chinesta, S, Socias, L, Solé-Violan, J, Suarez-Sipmann, F, Tamayo Lomas, L, Trenado, J, Úbeda, A, Jorge Valdivia, L, Vidal, P, Bermejo-Martin, J, Barbé, F & Torres, A 2025, 'Outcomes and predictors of mortality in patients with severe COVID-19 and COPD admitted to ICU : A multicenter study', Anaesthesia Critical Care and Pain Medicine, vol. 44, no. 5, 101558. https://doi.org/10.1016/j.accpm.2025.1015581769-6623https://hdl.handle.net/10641/6674Publisher Copyright: © 2025 The Authors. Published by Elsevier Masson SAS on behalf of Société Française d'Anesthésie et de Réanimation (SFAR). This is an open access article under the CC BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0/Background: High mortality rates among patients with chronic obstructive pulmonary disease (COPD) admitted to intensive care units (ICUs) during the COVID-19 pandemic highlight the need for tailored clinical management strategies. Study Design and Methods: Epidemiological, clinical, and laboratory data were collected in REDCap for 6512 patients hospitalized with COVID-19 across 55 Spanish ICUs. Patients were stratified into three groups: those with COPD, those with other chronic respiratory diseases (CRD), and those without respiratory comorbidities (No CRD). The primary outcome was to determine clinical predictors for 90-day mortality, focusing on the COPD group. A propensity score matching (PSM) method was applied to analyze the effects of respiratory support, biomarkers, and immunomarkers. Results: Patients with COPD (n = 328) exhibited a 50% mortality rate compared to 33% of those with other chronic respiratory diseases (CRD, n = 547), and those without respiratory comorbidities (No CRD, n = 5124). Among COPD patients, 95% of whom had Acute Respiratory Distress Syndrome (ARDS) due to COVID-19, the use of a high-flow nasal cannula (HFNC) was associated with reduced 90-day mortality (hazard ratio: 0.54 (95% Confidence Interval [0.31–0.95]). At a molecular scale, lower IgG levels but higher viral load and TNF-alpha, Vascular Cell Adhesion Molecule-1 (VCAM-1), and Fas Cell Surface Death Receptor (Fas) were associated with mortality in the COPD group. Conclusions: In COPD patients with ARDS due to COVID-19, the use of HFNC was associated with a better prognosis. The dysregulation in biomarkers and immunomarkers in COPD patients and its association with mortality highlight the need for further targeted therapeutic strategies.10836414enghttp://creativecommons.org/licenses/by-nc-nd/4.0/Acute respiratory distress syndromeBiomarkersChronic obstructive pulmonary diseaseHigh flow nasal cannulasRespiratory supportCritical Care and Intensive Care MedicineAnesthesiology and Pain MedicineSDG 3 - Good Health and Well-beingJournal ArticleMulticenter StudyYesyesjournal articleopen access10.1016/j.accpm.2025.101558https://www.scopus.com/pages/publications/105017807080https://www.scopus.com/pages/publications/105017807080#tab=citedBy