Gonzalez-Cucharero, ClaudiaVilahur, GemmaSaura, MartaHinojar, RocíoZamorano, Jose L.Zaragoza, Carlos2025-12-182025-12-182026-01Gonzalez-Cucharero, C, Vilahur, G, Saura, M, Hinojar, R, Zamorano, J L & Zaragoza, C 2026, 'Revisiting tricuspid regurgitation : Historical insights and emerging research perspectives', European Journal of Clinical Investigation, vol. 56, no. 1, e70138. https://doi.org/10.1111/eci.701380014-2972PubMedCentral: PMC12817247https://hdl.handle.net/10641/6693Publisher Copyright: © 2025 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.Background: Tricuspid regurgitation (TR), defined as the failure of proper leaflet coaptation during systole, is a common but often underrecognized valvular disorder. TR continues to rise, primarily due to population aging and the broader application of advanced diagnostic imaging techniques. Recent studies have established a clear association between TR and increased morbidity and mortality, thereby challenging its historical perception as a benign condition. Methods: The development of novel interventional therapies, combined with enhanced insight into the pathophysiology of right-sided heart failure, has prompted a shift towards earlier diagnosis and more proactive clinical management. Aim: Several gaps between novel scientific advancements and clinical translation still make this disease deserving of further attention. Discussion and Conclusion: In this review, we examine the most recent advances in understanding TR, which have enabled improved segmentation of affected patient populations. This progress has made it possible to identify key prognostic markers—particularly those related to disease progression—allowing for more accurate risk stratification and significantly more personalized treatment approaches.608269enghttp://creativecommons.org/licenses/by-nc-nd/4.0/arrhythmiasimagingmolecular markerspatient stratificationprognostic markerstricuspid regurgitationtricuspid valveGeneral MedicineBiochemistryClinical BiochemistryJournal ArticleReviewyesreview articleopen access10.1111/eci.70138https://www.scopus.com/pages/publications/105019689633https://www.scopus.com/pages/publications/105019689633#tab=citedBy