Pérez-Pozuelo, Juan ManuelHernández Iglesias, SonsolesPereira-Afonso, Mónica RaquelCheca-Peñalver, AbelGarcía-Valdivieso, InmaculadaLópez-González, ÁngelGómez-Cantarino, Sagrario2026-02-052026-02-052026Pérez-Pozuelo, J M, Hernández-Iglesias, S, Pereira-Afonso, M R, Checa-Peñalver, A, García-Valdivieso, I, López-González, Á & Gómez-Cantarino, S 2026, 'Effectiveness of non-pharmacological methods in reducing pain in pediatric patients and the role of nursing. Systematic review', Frontiers in Pediatrics, vol. 13, 1729847. https://doi.org/10.3389/fped.2025.17298472296-2360PubMedCentral: PMC12808490https://hdl.handle.net/10641/7855Publisher Copyright: 2026 Pérez-Pozuelo, Hernández-Iglesias, Pereira-Afonso, Checa-Peñalver, García-Valdivieso, López-González and Gómez-Cantarino.Introduction: The prevalence of pediatric pain has increased and is a leading cause of hospital attendance. Non-pharmacological treatments for pain relief in pediatrics are experiencing a boom. Methodology: Systematic review, following the quality guidelines of the PRISMA 2020 declaration. Previously determined inclusion and exclusion criteria were followed for the selection of studies. Results: The use of the vibrating and cold bee combined with a distractor is the most useful method, with virtual reality being the ideal distractor for the palliation of pediatric pain. The role of the nurse is essential to detect pain, choose the analgesia method and administer it. Discussion: The non-pharmacological techniques proposed and studied according to the selection of articles are useful in the reduction of pediatric pain according to the scales used in each study. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025640378, identifier CRD42025640378.12621782enghttp://creativecommons.org/licenses/by-nc-nd/4.0/non pharmacologicalnursingpain managementpediatricssystematic reviewPediatricsNursingPain managementSystematic reviewNon pharmacologicalPediatrics, Perinatology, and Child HealthJournal ArticleSystematic Reviewreview articleopen access10.3389/fped.2025.1729847https://www.scopus.com/pages/publications/105028102227https://www.scopus.com/pages/publications/105028102227#tab=citedByhttps://www.webofscience.com/wos/woscc/full-record/WOS:001663216900001