Abbad-Jaime de Aragon, CarlotaBerna-Rico, EmilioLecumberri, AlbaPerez-Bootello, JavierDavó-Mogica, MaríaNeria-Serrano, FernandoMonge, DianaBallester-Martínez, María AsunciónPindado-Ortega, CristinaCastellanos-González, MaríaLlamas-Velasco, MarWasniewski, SamanthaBarderas, María G.Jaén, PedroGelfand, Joel M.Mehta, Nehal N.Solís, JorgeFernández-Friera, LeticiaGonzález-Cantero, Álvaro2026-02-052026-02-052026-04Abbad-Jaime de Aragon, C, Berna-Rico, E, Lecumberri, A, Perez-Bootello, J, Davó-Mogica, M, Neria-Serrano, F, Monge, D, Ballester-Martínez, M A, Pindado-Ortega, C, Castellanos-González, M, Llamas-Velasco, M, Wasniewski, S, Barderas, M G, Jaén, P, Gelfand, J M, Mehta, N N, Solís, J, Fernández-Friera, L & González-Cantero, Á 2026, 'Prevalence, multiterritorial vascular distribution, and burden of subclinical atherosclerosis in psoriasis : The EDSAP study', JAAD International, vol. 25, pp. 44-55. https://doi.org/10.1016/j.jdin.2025.11.0262666-3287https://hdl.handle.net/10641/7856Publisher Copyright: © 2025 The Author(s)Background: Psoriasis increases atherosclerosis risk due to inflammation. To date, subclinical atherosclerosis (SA) in psoriasis has only been studied in individual vascular territories by imaging. Objective: To conduct a comprehensive evaluation of multiterritorial SA prevalence in psoriasis by imaging and establish its relationships with cardiovascular (CV) risk scores. Methods: A total of 120 patients with moderate-to-severe psoriasis without CV disease from the Early Detection of Subclinical Atherosclerosis in Psoriasis (EDSAP) cohort underwent vascular ultrasound of carotid/femoral arteries and noncontrast/contrast-coronary computed tomography angiography. SA was defined by the presence of any plaque or a coronary artery calcium score ≥1. Results: The median age was 48.04 (8.25) years, 73% were male, and 77% of participants had SA. Femoral arteries were most affected (57.1%), followed by the coronaries (51.3%) and carotid arteries (49.6%). Femoral plaques exhibited the strongest associations with coronary parameters. CV risk scores underestimated SA, as at least 60% low-risk and 90% moderate-risk patients had SA. Limitations: The main limitation is the small sample size. Conclusions: This study provides the first multiterritorial assessment of SA in psoriasis, revealing a high prevalence of early disease. Femoral arteries were most affected, correlating with coronary atherosclerosis. The high SA detection within low-/intermediate-risk individuals suggests recalibrating CV scores for establishing effective preventive measures.124013090enghttp://creativecommons.org/licenses/by-nc-nd/4.0/atherosclerosiscardiovascular diseaseepidemiologyinflammationpsoriasisPsoriasisAtherosclerosisCardiovascular diseaseInflammationEpidemiologyDermatologySDG 3 - Good Health and Well-beingYesyesjournal articleopen access10.1016/j.jdin.2025.11.026https://www.scopus.com/pages/publications/105028487587https://www.scopus.com/pages/publications/105028487587#tab=citedBy