Clinical, histopathological and ultrastructural features of human monkeypox infection in the 2022 outbreak: report of a case with immunohistochemistry for vaccinia virus.

Prieto Pérez, LauraVicente Montaña, Ana MaríaSantonja, C.Fortes, J.García Fresnadillo, D.Jo-Velasco, M.Requena, L.Cabello, A.Fernández Roblas, R.Álvarez, B.Carrillo, I.Górgolas, M.2024-12-042024-12-042022Prieto-Pérez, L., Vicente Montaña, A., Santonja, C. et al. (2022) Clinical, histopathological and ultrastructural features of human monkeypox infection in the 2022 outbreak: report of a case with immunohistochemistry for vaccinia virus, Clinical and Experimental Dermatology, Vol. 48, Núm. 1, pp. 60–63.0307-6938https://hdl.handle.net/10641/5511Human monkeypox (HMPX) is an emerging viral zoonosis that has now become the most prevalent Orthopoxvirus worldwide.1 The Poxviridae family is formed by large, double-stranded DNA viruses that replicate in vertebrate cells. Currently, there is a substantial outbreak of HMPX, with more than 64 200 cases reported to date. Reports on the histology and ultrastructure of the current HMPX are currently scarce. We describe the clinical, histological, immunohistochemical and ultrastructural features of the current HMPX virus, emphasizing the applicability of both transmission electron microscopy (TEM) and immunohistochemistry (IHC) for a fast visualization and identification of viruses.spaAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/Clinical, histopathological and ultrastructural features of human monkeypox infection in the 2022 outbreak: report of a case with immunohistochemistry for vaccinia virus.journal articleopen access10.1093/ced/llac020