García Adrián, SilviaIglesias Pérez, ClaudiaCarmona-Bayonas, AlbertoOrtega Morán, LauraRubio Pérez, Jaimedel Prado, Purificación Martínezde Castro, Eva MartínezNeria, FernandoFernández Pérez, Isaurade Herreros, Marta GarcíaCarmona Campos, MartaGarcía Escobar, IgnacioPorta Balanyà, RutMarrupe González, DavidJiménez Fonseca, PaulaGuirao García, María EsperanzaSánchez Cánovas, ManuelMuñoz Langa, JoséPérez Segura, PedroMéndez Vidal, Ma JoséMuñoz Martín, Andrés J.2026-01-272026-01-272025-07García Adrián, S, Iglesias Pérez, C, Carmona-Bayonas, A, Ortega Morán, L, Rubio Pérez, J, del Prado, P M, de Castro, E M, Neria, F, Fernández Pérez, I, de Herreros, M G, Carmona Campos, M, García Escobar, I, Porta Balanyà, R, Marrupe González, D, Jiménez Fonseca, P, Guirao García, M E, Sánchez Cánovas, M, Muñoz Langa, J, Pérez Segura, P, Méndez Vidal, M J & Muñoz Martín, A J 2025, 'Cancer-related thrombosis : impact of biological sex on the risk of rethrombosis and bleeding', Haematologica, vol. 110, no. 7, pp. 1513-1522. https://doi.org/10.3324/haematol.2024.2861520390-6078PubMedCentral: PMC12208159unpaywall: 10.3324/haematol.2024.286152https://hdl.handle.net/10641/7557Publisher Copyright: ©2025 Ferrata Storti Foundation.Patients with cancer have a higher risk of re-thrombosis and bleeding secondary to anticoagulant treatment than have individuals without cancer. Given the lack of specific clinical trials, the decision regarding the optimal duration of treatment must consider multiple factors, including sex. The current study used data from the international, prospective TESEO Registry that includes consecutive patients diagnosed with cancer-associated thrombosis. Between July 2018 and December 2022, 2,823 patients were included in the TESEO Registry, 1,351 (48%) of whom were female. The most common venous thromboembolic event (VTE) in both sexes was pulmonary embolism, with an incidence of 58.0% among men and 54.3% in women (P=0.045). After a median follow-up of 6.9 months (interquartile range, 1.9-14.4), the re-thrombosis rate at the end of follow-up was 10.0% in males and 15.0% in females (P=0.14). The location of the primary tumor in the gastrointestinal tract was associated with a greater risk of re-thrombosis, whereas sex had no significant impact. Men had twice as many major bleeds. Additional risk factors for major bleeding included situations of risk due to tumor site or thrombocytopenia, as well as the presence of active tumor bleeding at the time of VTE diagnosis. Overall survival was longer among women. Given the higher incidence of major bleeding among men, sex should be deemed a relevant factor when deciding the duration of anticoagulant treatment in cancer patients.101575233enghttp://creativecommons.org/licenses/by-nc-nd/4.0/HematologySDG 3 - Good Health and Well-beingJournal ArticleYesyesjournal articleopen access10.3324/haematol.2024.286152https://www.scopus.com/pages/publications/105009637239https://www.scopus.com/pages/publications/105009637239#tab=citedBy