SCOURGE Cohort Group2026-01-142026-01-142024-10-03SCOURGE Cohort Group 2024, 'Novel risk loci for COVID-19 hospitalization among admixed American populations', eLife, vol. 13. https://doi.org/10.7554/eLife.936662050-084XPubMedCentral: PMC11449485https://hdl.handle.net/10641/7269Publisher Copyright: © 2024, Diz-de Almeida, Cruz et al.The genetic basis of severe COVID-19 has been thoroughly studied, and many genetic risk factors shared between populations have been identified. However, reduced sample sizes from non-European groups have limited the discovery of population-specific common risk loci. In this second study nested in the SCOURGE consortium, we conducted a genome-wide association study (GWAS) for COVID-19 hospitalization in admixed Americans, comprising a total of 4702 hospitalized cases recruited by SCOURGE and seven other participating studies in the COVID-19 Host Genetic Initiative. We identified four genome-wide significant associations, two of which constitute novel loci and were first discovered in Latin American populations (BAZ2B and DDIAS). A trans-ethnic meta-analysis revealed another novel cross-population risk locus in CREBBP. Finally, we assessed the performance of a cross-ancestry polygenic risk score in the SCOURGE admixed American cohort. This study constitutes the largest GWAS for COVID-19 hospitalization in admixed Latin Americans conducted to date. This allowed to reveal novel risk loci and emphasize the need of considering the diversity of populations in genomic research.2820539enghttp://creativecommons.org/licenses/by-nc-nd/4.0/COVID-19GWASSNPgeneticsgenomicsnoneGeneral NeuroscienceGeneral Biochemistry, Genetics and Molecular BiologyGeneral Immunology and MicrobiologyJournal ArticleYesyesjournal articleopen access10.7554/eLife.93666https://www.scopus.com/pages/publications/85205526863https://www.scopus.com/pages/publications/85205526863#tab=citedBy