Val-Blasco, AlmudenaZaragoza Sánchez, CarlosFernández-Velasco, María2022-09-122022-09-1220222452-302Xhttp://hdl.handle.net/10641/3092Highlights • Administration of BML-111, a stable LXA4 analog, protects against cardiac dysfunction by avoiding Ca2+ mishandling induced by autoimmune myocarditis in a mouse model. • Beneficial effects of the SPMs on intracellular Ca2+ handling are mainly caused by a regulation of SERCA2A by NRF2. • Cardiac tissue obtained from individuals diagnosed with myocarditis, compared with healthy myocardium tissues, displayed depressed mRNA levels of ATP2A2 (SERCA2A) and NF2L2 (NRF2).engAtribución-NoComercial-SinDerivadas 3.0 Españahttp://creativecommons.org/licenses/by-nc-nd/3.0/es/Calcium handlingMyocarditisPro-resolving mediatorsjournal articleopen access10.1016/j.jacbts.2022.01.009