What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation.
Autor: Orgaz, José L.; Sanz Moreno, Victoria
Resumen: Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for
cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is
also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from
reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid
populations to establish immunosuppression (extrinsic).
Identificador universal: http://hdl.handle.net/10641/2302
Fecha: 2020
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