dc.contributor.author | Soria, Federico | |
dc.contributor.author | Martínez-Pla, Luna | |
dc.contributor.author | Aznar-Cervantes, Salvador D. | |
dc.contributor.author | De la Cruz, Julia E. | |
dc.contributor.author | Fernández, Tomás | |
dc.contributor.author | Pérez-Fentes, Daniel | |
dc.contributor.author | Llanes González, Luis | |
dc.contributor.author | Sánchez-Margallo, Francisco Miguel | |
dc.date.accessioned | 2023-12-22T11:15:20Z | |
dc.date.available | 2023-12-22T11:15:20Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2073-4360 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/3611 | |
dc.description.abstract | Urothelial tumour of the upper urinary tract is a rare neoplasm, but unfortunately, it
has a high recurrence rate. The reduction of these tumour recurrences could be achieved by the
intracavitary instillation of adjuvant chemotherapy after nephron-sparing treatment in selected
patients, but current instillation methods are ineffective. Therefore, the aim of this in vitro study is
to evaluate the cytotoxic capacity of a new instillation technology through a biodegradable ureteral
stent/scaffold coated with a silk fibroin matrix for the controlled release of mitomycin C as an
anti-cancer drug. Through a comparative study, we assessed, in urothelial carcinoma cells in a human
cancer T24 cell culture for 3 and 6 h, the cytotoxic capacity of mitomycin C by viability assay using
the CCK-8 test (Cell counting Kit-8). Cell viability studies in the urothelial carcinoma cell line confirm
that mitomycin C embedded in the polymeric matrix does not alter its cytotoxic properties and causes
a significant decrease in cell viability at 6 h versus in the control groups. These findings have a clear
biomedical application and could be of great use to decrease the recurrence rate in patients with
upper tract urothelial carcinomas by increasing the dwell time of anti-cancer drugs. | spa |
dc.language.iso | eng | spa |
dc.publisher | Polymers | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Ureteral stent | spa |
dc.subject | Biodegradable stent | spa |
dc.subject | Cell viability assessment | spa |
dc.subject | Chemotherapy | spa |
dc.subject | UTUC | spa |
dc.title | Cytotoxicity Assessment of a New Design for a Biodegradable Ureteral Mitomycin Drug-Eluting Stent in Urothelial Carcinoma Cell Culture. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dc.rights.accessRights | open access | spa |
dc.description.extent | 1,13 MB | spa |
dc.identifier.doi | 10.3390/polym14194081 | spa |
dc.relation.publisherversion | https://www.mdpi.com/2073-4360/14/19/4081 | spa |