Browsing by Author "Miguel-Castro, Marta"
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Item Antioxidant, Angiotensin-Converting Enzyme Inhibitory Properties and Blood-Pressure-Lowering Effect of Rice Bran Protein Hydrolysates(Foods, 2020) Brose Piotrowicz, Inajara Beatriz; Garcés Rimón, Marta; Moreno Fernández, Silvia; Aleixandre, Amaya; Salas-Mellado, Myriam; Miguel-Castro, MartaItem Effect of Nutrition Education on Health Science University Students to Improve Cardiometabolic Profile and Inflammatory Status.(Nutrients, 2023) López Moreno, Miguel; Garcés Rimón, Marta; Miguel-Castro, Marta; Fernández-Martínez, Elia; Iglesias López, María TeresaThe inadequate lifestyle associated with university life may have a negative impact on various cardiometabolic factors. The aim of this study was to evaluate the effect of a one-year nutrition education course on cardiometabolic parameters in undergraduate health science students. During the 2021–22 academic year, 1.30 h nutrition sessions were conducted twice a week. Capillary blood samples were collected and centrifuged to measure cardiometabolic and inflammatory biomarkers in serum. The sample studied consisted of 49 students: 20.4% male and 79.6% female. The nutritional intervention resulted in changes in dietary patterns, with increased consumption of vegetables, nuts and legumes. After the course, females showed an increase in HDL-cholesterol levels (p = 0.007) and no change in LDL-cholesterol levels (p = 0.189). On the other hand, males showed significant changes in HDL-cholesterol (p = 0.001) and LDL-cholesterol (p = 0.043) levels. The atherogenic index was also significantly reduced (p < 0.001) in both males (p = 0.009) and females (p = 0.002). Differences were also observed in the increase in vitamin D levels in both males and females, although the magnitude of the increase was greater in the men (Δ = 7.94, p = 0.016 in men vs. Δ = 4.96, p = 0.001 in women). The monocyte-to-HDL ratio (MHR) showed a significant reduction, although these differences were only significant in males. Students with low vitamin D levels had higher LDL-cholesterol values (p = 0.01) and atherogenic index (p = 0.029). Adjusted linear regression analysis showed a significant association between post-course vitamin D MHR (β = −0.42, IC: −0.29, −0.06, p < 0.01). These findings suggest the importance of including nutrition education programs during the university stage for the prevention of long-term health problems.Item Potential Role of Bioactive Proteins and Peptides Derived from Legumes towards Metabolic Syndrome.(Nutrients, 2022) Garcés Rimón, Marta; Morales, Diego; Miguel-Castro, MartaLegumes have been widely consumed and used to isolate bioactive compounds, mainly proteins. The aim of this study was to review the beneficial actions of different legumes proteins and peptides updating the main findings that correlate legumes consumption and the effects on non-transmissible chronic diseases, specifically metabolic syndrome. An exhaustive revision of five relevant bioactivities (antioxidant, anti-inflammatory, antihypertensive, hypocholesterolemic -all of them linked to metabolic syndrome- and antitumoral) of proteins and peptides from legumes focused on isolation and purification, enzymatic hydrolysis and in vitro gastrointestinal digestion was carried out. The promising potential of bioactive hydrolysates and peptides from pulses has been demonstrated by in vitro tests. However, only a few studies validated these biological activities using animal models. No clinical trials have been carried out yet; so further research is required to elucidate their effective health implications.Item Red Quinoa hydrolysates with antioxidant bioactive properties on oxidative stress-induced Saccharomyces cerevisiae.(LWT. Food Science and Technology, 2023) López Moreno, Miguel; Sabater-Muñoz, Beatriz; Iglesias López, María Teresa; Miguel-Castro, Marta; Garcés Rimón, MartaQuinoa (Chenopodium quinoa Willd) is a pseudo-cereal of great interest for its nutritional value. Specifically, enzymatic hydrolysis of quinoa proteins has shown several biological activities. The purpose of this study was to investigate the influence of enzymatic hydrolysis on antioxidant by the oxygen radical absorbance capacity (ORAC) method and sensory properties of white, red and black quinoa varieties, and to evaluate the in vivo antioxidant capacity of the most promising quinoa hydrolysate using Saccharomyces cerevisiae BY4741 as an experimental model. The results showed a hydrolysate from red quinoa seeds with a promising sensory profile and antioxidant activity. Although more studies in experimental models and human trials will be necessary to corroborate the antioxidant effect and the mechanisms of action involved, the results obtained may allow the development of new plant-based foods with antioxidant properties scientifically supported and useful in the prevention and/or the treatment of pathologies related to oxidative stress.Item Red Quinoa Hydrolysates with Antioxidant Properties Improve Cardiovascular Health in Spontaneously Hypertensive Rats.(Antioxidants, 2023) López Moreno, Miguel; Jiménez-Moreno, Estefanía; Márquez Gallego, Antonio; Vera Pasamontes, Gema; Uranga Ocio, José Antonio; Garcés Rimón, Marta; Miguel-Castro, MartaIn recent years, quinoa has been postulated as an emerging crop for the production of functional foods. Quinoa has been used to obtain plant protein hydrolysates with in vitro biological activity. The aim of the present study was to evaluate the beneficial effect of red quinoa hydrolysate (QrH) on oxidative stress and cardiovascular health in an in vivo experimental model of hypertension (HTN) in the spontaneously hypertensive rat (SHR). The oral administration of QrH at 1000 mg/kg/day (QrHH) showed a significant reduction in SBP from baseline (−9.8 ± 4.5 mm Hg; p < 0.05) in SHR. The mechanical stimulation thresholds did not change during the study QrH groups, whereas in the case of SHR control and SHR vitamin C, a significant reduction was observed (p < 0.05). The SHR QrHH exhibited higher antioxidant capacity in the kidney than the other experimental groups (p < 0.05). The SHR QrHH group showed an increase in reduced glutathione levels in the liver compared to the SHR control group (p < 0.05). In relation to lipid peroxidation, SHR QrHH exhibited a significant decrease in plasma, kidney and heart malondialdehyde (MDA) values compared to the SHR control group (p < 0.05). The results obtained revealed the in vivo antioxidant effect of QrH and its ability to ameliorate HTN and its associated complications.