Person: Cristóbal García, Ignacio
Loading...
First Name
Ignacio
Last Name
Cristóbal García
Affiliation
Faculty
Medicina
Department
Area
Identifiers
23 results
Search Results
Now showing 1 - 10 of 23
Item The new LNG-releasing IUS: a new opportunity to reduce the burden of unintended pregnancy.(European Journal of Obstetrics and Gynecology and Reproductive Biology, 2015) Cristóbal García, Ignacio; Neyro, José Luis; Lete, IñakiUnintended pregnancies still remain a worldwide public health problem. They have received much attention in adolescents given the strong impact they have on their present and future lives. On the other side, as women join the labour market, young women wishing to delay maternity are also especially vulnerable. Studies have revealed a pattern of use of contraceptive methods that is likely to increase this risk. Methods of long-acting reversible contraception (LARC), among which cooper and levonorgestrel-releasing intrauterine devices (IUD and IUS) are the most common, have been widely recommended to avoid unintended pregnancy at any age. Despite this, the use of these devices is very limited. Several barriers to their wide spread use have been identified, which specially affect a higher use by nulliparous women. A new levonorgestrel-releasing IUS containing only 13.5 mg of levonorgestrel (IUS12), recently marketed as Jaydess® in Europe, which provides a smaller size, a shorter duration of action, and a lower hormonal content compared to Mirena®, along with a similar efficacy and safety profile, may offer a long-term option that better addresses the needs of nulliparous women. Evidence on the risk of unintended pregnancies in young women –with a special emphasis in Europe—, barriers associated with a lower-than-desirable use of LARC methods –especially intrauterine devices (IUD and IUS)—, and the potential benefits of the new IUS12 including changes in bleeding pattern, safety and user satisfaction –especially with respect to nulliparous and adolescents— are reviewed here. Evidence supports that IUS12 may offer a LARC option that better addresses the needs of these women.Item Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer.(Journal of Pathology, 2017) Rynne-Vidal, Angela; Au-Yeung, Chi Lam; Jiménez-Heffernan, José A.; Pérez-Lozano, María Luisa; Cremades-Jimeno, Lucía; Bárcena, Carmen; Cristóbal García, Ignacio; Fernández-Chacón, Concepción; Yeung, Tsz Lun; C Mok, Samuel; Sandoval, Pilar; López Cabrera, ManuelPeritoneal dissemination is the primary metastatic route of ovarian cancer (OvCa), and is often accompanied by the accumulation of ascitic fluid. The peritoneal cavity is lined by mesothelial cells (MCs), which can be converted into carcinoma-associated fibroblasts (CAFs) through mesothelial-to-mesenchymal transition (MMT). Here, we demonstrate that MCs isolated from ascitic fluid (AFMCs) of OvCa patients with peritoneal implants also undergo MMT and promote subcutaneous tumour growth in mice. RNA sequencing of AFMCs revealed that MMT-related pathways – including transforming growth factor (TGF)- signalling – are differentially regulated, and a gene signature was verified in peritoneal implants from OvCa patients. In a mouse model, pre-induction of MMT resulted in increased peritoneal tumour growth, whereas interfering with the TGF- receptor reduced metastasis. MC-derived CAFs showed activation of Smad-dependent TGF- signalling, which was disrupted in OvCa cells, despite their elevated TGF- production. Accordingly, targeting Smad-dependent signalling in the peritoneal pre-metastatic niche in mice reduced tumour colonization, suggesting that Smad-dependent MMT could be crucial in peritoneal carcinomatosis. Together, these results indicate that bidirectional communication between OvCa cells and MC-derived CAFs, via TGF--mediated MMT, seems to be crucial to form a suitable metastatic niche. We suggest MMT as a possible target for therapeutic intervention and a potential source of biomarkers for improving OvCa diagnosis and/or prognosis.Item Validación de la versión española del Cuestionario Uterine Fibroid Symptom and Quality of Life (UFS-QoL) en mujeres con miomatosis uterina.(Medicina Clínica, 2019) Calaf, Joaquim; Palacios, Santiago; Cristóbal García, Ignacio; Cañete, María Luisa; Monleón, Javier; Fernández, Jorge; Hernández, Alicia; Vázquez, FranciscoOBJETIVO: Validar la versión española del Cuestionario Uterine Fibroid Symptom and Quality of Life (UFS-QoL) en mujeres con miomatosis uterina para evaluar la gravedad de los síntomas y su impacto en la calidad de vida relacionada con la salud. MÉTODOS: Las pacientes fueron reclutadas en consultas de ginecología. El Cuestionario UFS-QoL consta de 37 ítems, 8 de los cuales evalúan la gravedad de los síntomas, mientras que los 29 restantes evalúan la calidad de vida relacionada con la salud (CVRS) en 6 subescalas. Se determinaron la consistencia interna, la validez concurrente y discriminante, la fiabilidad test-retest y la sensibilidad al cambio de la escala. RESULTADOS: Un total de 619 pacientes con miomatosis uterina y 57 mujeres sin miomatosis participaron en el estudio. El coeficiente alfa de Cronbach fue de 0,97 y la fiabilidad test-retest de 0,90 para la escala global. El Cuestionario UFS-QoL no solo discriminó entre pacientes y controles normales sino también entre pacientes con distintos grados de miomatosis uterina. Asimismo la escala respondió a los cambios tras el tratamiento, con un tamaño de efecto de 1.2. CONCLUSIÓNES: La versión española del Cuestionario UFS-QoL, administrada en una muestra de la población española, ha demostrado ser una herramienta válida y fiable para diferenciar las pacientes con miomatosis uterina con diferentes grados de síntomas y valorar el impacto de la gravedad de estos síntomas en la calidad de vida relacionada con la salud. Además, el UFS-QoL ha demostrado ser sensible a los cambios generados por el tratamiento de la miomatosis.Item Bone protection during breast cancer treatment.(Revista de Osteoporosis y Metabolismo Mineral, 2020) Neyro, J.L.; Cristóbal García, Ignacio; Palacios, S.Item Effectiveness of nonhormonal products for the treatment of women with vaginal atrophy. [Efectividad de productos no hormonales para el tratamiento de las mujeres con atrofia vaginal].(Progresos de obstetricia y ginecología., 2019) Cristóbal García, Ignacio; Lorite Aguilera, Lidia; Álvarez Martinez, Esperanza; Piedrabuena, VerónicaObjective: To describe the clinical progress of women with vaginal atrophy who receive nonhormonal treatment. Material and methods: Single-center retrospective longitudinal observational descriptive study in postmenopausal women aged 45-60 years with symptoms of vaginal atrophy who required nonhormonal treatment. Results: We included 98 women with a mean (SD) age of 54.6 (3.2) years and a mean time of 5.6 (3.0) years without menstrual periods. Of these, 63.3% were treated with hyaluronic acid and Centella asiatica cell lysate and the other 36.7% with glycerin and polycarbophil. The vaginal maturation index improved significantly after 3 months of treatment with hyaluronic acid and Centella asiatica: the parabasal cell count declined (-8.4%; 95%CI, –10.6 to –6.2; p=0.001) and the intermediate cell count increased (3.6%; 95%CI, 2.0-5.3; p=0.001), as did that of superficial cells (4.8%; 95%CI, 3.8-5.7; p=0.001). In addition, all symptoms and signs of vaginal atrophy improved after 3 months with treatment with hyaluronic acid and Centella asiatica lysate. There was no significant change in the vaginal maturation index or in symptoms and signs after 3 months of treatment with glycerin and polycarbophil. Conclusions: Three months of nonhormonal treatment with hyaluronic acid and Centella asiatica lysate significantly improved the vaginal maturation index.Item La anticoncepción del siglo XXI; desde la prevención de embarazos no deseados a la mejora integral de la calidad de vida.(Ginecología y Obstetricia de México, 2020) Neyro, José Luis; Celis-Gonzélz, Cuauhtémoc; Cristóbal García, IgnacioItem One year quality of life measured with SEC-QoL in levonorgestrel 52 mg IUS users.(Contraception, 2017) Cristóbal García, Ignacio; Lete, Luis Ignacio; De la Viuda, Esther; Perulero, Nuria; Arbart, Agnes; Canals, IgnasiObjectives: The present study aims to prospectively evaluate quality of life (QoL) of women using 52 mg levonorgestrel intrauterine system for contraception determined through the SEC-QoL, a questionnaire specifically designed to assess the impact of contraceptive methods on QoL of fertile women. Study design: We conducted a prospective observational multicenter study of 201 reproductive age women who initiated the levonorgestrel intrauterine system (LNGIUS) for contraception. Sociodemographic and clinical data were collected at baseline and 12 months afterwards. Participants filled in the SEC-QoL questionnaire at both visits. SEQ-QoL scores range from 0 (worst QoL) to 100 (best QoL). Results: Participants claimed an increased QoL 12 months after insertion in all five dimensions of SEC-QoL due to its high contraceptive efficacy and its capability to reduce other menstrual symptoms (e.g. heavy menstrual bleeding or dysmenorrhoea), overall exerting a positive impact on user’s satisfaction. SEC-QoL general overall score went from a mean (SD) score of 46.3 (17.3) at baseline to 72.2 (14.8) 12 months afterwards (p<0.001). Overall, 94.6% of women claimed having found additional benefits other than contraception. No pregnancies were reported during the 12 months of study duration and only 14 women discontinued use of LNG-IUS (only two of them due to an adverse event), representing a continuation rate of 93%. Conclusions: Women using LNG-IUS for contraception have an increased QoL after 12 months of use, demonstrated by the increased score in all dimensions of the SEC-QoL questionnaire.Item The Effect of Virtual Reality on the Reduction of Pain in Women with an Indication for Outpatient Diagnostic Hysteroscopy: A Randomized Controlled Trial.(Journal of Clinical Medicine, 2023) Pelazas-Hernández, Jesus A.; Varillas Delgado, David; González-Casado, Teresa; Cristóbal Quevedo, Ignacio; Alonso-Bermejo, Agustina; Ronchas-Martínez, Marina; Cristóbal García, IgnacioBackground: The cognitive distraction caused by Virtual Reality (VR) seems to cause a decrease both in pain and its perception as in the time spent thinking about possible pain, among anxiety about hysteroscopy procedure. The main objective of this investigation was to evaluate the efficacy of virtual reality for pain relief during outpatient hysteroscopy. Method: A total of 83 patients underwent outpatient diagnostic hysteroscopy in a single-centre, open-label, randomized control trial. Overall, 180 women with medical indication for an outpatient diagnostic hysteroscopy were randomized. Ten were excluded due to the impossibility of entering the endometrial cavity caused by a cervical canal that was not permeable, and 15 did not tolerate the pain at the beginning and during the procedure, excluding themselves from the final model. Finally, 154 were analysed per protocol to use VR (n = 82, study group) or standard treatment (n = 72, control group) assessing the differences between both groups by reduction in pain using Visual Analogue Scale score (VAS: 0–10 cm) and clinical data (arterial pressure, heart rate, and oxygen saturation) at the end of hysteroscopy, at 15 and 30 min after hysteroscopy. Results: Women with VR outpatient diagnostic hysteroscopy experienced less pain at final (VAS score 2.451 vs. 3.972, standard mean difference (SMD) −1.521, 95% CI −2.601 to −0.440; p = 0.006), at 15 min (VAS 1.769 vs. 3.300, SMD −1.531, 95% CI −2.557 to −0.504; p = 0.004), and at 30 min (VAS 1.621 vs. 2.719, SMD −1.099, 95% CI −2.166 to −0.031; p = 0.044) after the ending of the hysteroscopy, compared with no VR. Conclusions: The use of VR during outpatient diagnostic hysteroscopy proved effective in the reduction of pain in this randomized control trial. It shows wide potential role in ambulatory gynaecologic procedures to avoid repeating tests, perform surgeries without anaesthesia, and the use of medication and its side effects.Item COVID-19 and Pregnancy: Citation Network Analysis and Evidence Synthesis.(JMIR Pediatrics and Parenting, 2022) Ruiz-Roman, Rebeca; Martinez-Perez, Clara; Gil Prados, Inés; Cristóbal García, Ignacio; Sánchez-Tena, Miguel ÁngelBackground: COVID-19 spread quickly around the world shortly after the first outbreaks of the new coronavirus disease at the end of December 2019, affecting all populations, including pregnant women. Objective: The aim of this study was to analyze the relationship between different publications on COVID-19 in pregnancy and their authors through citation networks, as well as to identify the research areas and to determine the publication that has been the most highly cited. Methods: The search for publications was carried out through the Web of Science database using terms such as “pregnancy,” “SARS-CoV-2,” “pregnant,” and “COVID-19” for the period between January and December 2020. Citation Network Explorer software was used for publication analysis and VOSviewer software was used to construct the figures. This approach enabled an in-depth network analysis to visualize the connections between the related elements and explain their network structure. Results: A total of 1330 publications and 5531 citation networks were identified in the search, with July being the month with the largest number of publications, and the United States, China, and England as the countries with the greatest number of publications. The most cited publication was “Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records” by Chen and colleagues, which was published in March 2020. Six groups identified as being close in the citation network reflect multidisciplinary research, including clinical characteristics and outcomes in pregnancy, vertical transmission, delivery mode, and psychological impacts of the pandemic on pregnant women. Conclusions: Thousands of articles on COVID-19 have been published in several journals since the disease first emerged. Identifying relevant publications and obtaining a global view of the main papers published on COVID-19 and pregnancy can lead to a better understanding of the topic. With the accumulation of scientific knowledge, we now know that the clinical features of COVID-19 during pregnancy are generally similar to those of infected nonpregnant women. There is a small increase in frequency of preterm birth and cesarean birth, related to severe maternal illness. Vaccination for all pregnant women is recommended. Several agents are being evaluated for the treatment of COVID-19, but with minimal or no information on safety in pregnancy. These results could form the basis for further research. Future bibliometric and scientometric studies on COVID-19 should provide updated information to analyze other relevant indicators in this field.Item Papel actual del acetato de ulipristal en el tratamiento de los síntomas asociados a los miomas uterinos. [Current role of ulipristal acetate in the management of uterine fibroids.](Progresos de obstetricia y ginecología., 2019) Goitia Ibarra, Mikel; Cristóbal García, Ignacio; Monleón Sancho, Javier; Oña López, María Rosa; Raga Baixauli, Francisco; Cañete Palomo, María Luisa; Fernández Parra, Jorge; Abellán-García Sánchez, Fernando; Hernández Gutiérrez, Alicia; Gracia Quero, Meritxell; Carmona Herrera, Francisco
- «
- 1 (current)
- 2
- 3
- »