Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity : Entrainment of Metabolic and Brain Functions

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URI: https://hdl.handle.net/10641/6789
ISSN: 2073-4409
DOI: 10.3390/cells14171325

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2025-09

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Insulin-like growth factor I (IGF-I) is a neurotrophic factor that regulates neurogenesis, synaptogenesis, and neuronal survival. It also enhances neuronal activity and facilitates synaptic plasticity. Additionally, IGF-I plays a critical role in the regulation of metabolism in mammals. Emerging evidence indicates that IGF-I modulates sleep architecture. The circadian integration of metabolic and neuronal systems serves to optimize energy utilization across the light/dark cycle. Current data suggest that IGF-I may be a key mediator of this integration, promoting brain activity during wakefulness, a state that coincides with increased metabolic demand. In this review, we summarize recent findings on the interplay between metabolism, IGF-I, and brain activity.

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Publisher Copyright: © 2025 by the authors.

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IGF-I, cholinergic neurons, circadian rhythms, electrocorticogram, growth hormone, orexinergic neurons, synaptic plasticity, General Biochemistry, Genetics and Molecular Biology, Journal Article, Review, Yes, yes

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García-Magro, N, Mesa-Lombardo, A & Nuñez, Á 2025, 'Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity : Entrainment of Metabolic and Brain Functions', Cells, vol. 14, no. 17, 1325. https://doi.org/10.3390/cells14171325

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FACULTAD DE CIENCIAS DE LA SALUD