Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of MiceWas Reduced in Aging.
Loading...
Identifiers
Publication date
2022
Start date of the public exhibition period
End date of the public exhibition period
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Cells
Share
Abstract
Aging is accompanied by a decline in cognition that can be due to a lower IGF-I level. We
studied response facilitation induced in primary somatosensory (S1) cortical neurons by repetitive
stimulation of whiskers in young and old mice. Layer 2/3 and 5/6 neurons were extracellularly
recorded in young ( 6 months of age) and old ( 20 month of age) anesthetized mice. IGF-I injection
in S1 cortex (10 nM; 0.2 L) increased whisker responses in young and old animals. A stimulation
train at 8 Hz induced a long-lasting response facilitation in only layer 2/3 neurons of young animals.
However, all cortical neurons from young and old animals showed long-lasting response facilitation
when IGF-I was applied in the S1 cortex. The reduction in response facilitation in old animals can
be due to a reduction in the IGF-I receptors as was indicated by the immunohistochemistry study.
Furthermore, a reduction in the performance of a whisker discrimination task was observed in old
animals. In conclusion, our findings indicate that there is a reduction in the synaptic plasticity of S1
neurons during aging that can be recovered by IGF-I. Therefore, it opens the possibility of use IGF-I
as a therapeutic tool to ameliorate the effects of heathy aging.
Doctoral program
Description
Keywords
S1 cortex, Response facilitation, Aging