Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of MiceWas Reduced in Aging.
dc.contributor.author | García Magro, Nuria | |
dc.contributor.author | Zegarra-Valdivia, Jonathan A. | |
dc.contributor.author | Troyas-Martinez, Sara | |
dc.contributor.author | Torres-Aleman, Ignacio | |
dc.contributor.author | Nuñez, Angel | |
dc.date.accessioned | 2022-04-25T10:35:32Z | |
dc.date.available | 2022-04-25T10:35:32Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Aging is accompanied by a decline in cognition that can be due to a lower IGF-I level. We studied response facilitation induced in primary somatosensory (S1) cortical neurons by repetitive stimulation of whiskers in young and old mice. Layer 2/3 and 5/6 neurons were extracellularly recorded in young ( 6 months of age) and old ( 20 month of age) anesthetized mice. IGF-I injection in S1 cortex (10 nM; 0.2 L) increased whisker responses in young and old animals. A stimulation train at 8 Hz induced a long-lasting response facilitation in only layer 2/3 neurons of young animals. However, all cortical neurons from young and old animals showed long-lasting response facilitation when IGF-I was applied in the S1 cortex. The reduction in response facilitation in old animals can be due to a reduction in the IGF-I receptors as was indicated by the immunohistochemistry study. Furthermore, a reduction in the performance of a whisker discrimination task was observed in old animals. In conclusion, our findings indicate that there is a reduction in the synaptic plasticity of S1 neurons during aging that can be recovered by IGF-I. Therefore, it opens the possibility of use IGF-I as a therapeutic tool to ameliorate the effects of heathy aging. | spa |
dc.description.extent | 2685 KB | spa |
dc.identifier.doi | 10.3390/cells11040717 | spa |
dc.identifier.issn | 2073-4409 | spa |
dc.identifier.uri | http://hdl.handle.net/10641/2934 | |
dc.language.iso | eng | spa |
dc.publisher | Cells | spa |
dc.relation.publisherversion | https://www.mdpi.com/2073-4409/11/4/717 | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | S1 cortex | spa |
dc.subject | Response facilitation | spa |
dc.subject | Aging | spa |
dc.title | Response Facilitation Induced by Insulin-like Growth Factor-I in the Primary Somatosensory Cortex of MiceWas Reduced in Aging. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dspace.entity.type | Publication |
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