Marked bias towards spontaneous synaptic inhibition distinguishes non-adapting from adapting layer 5 pyramidal neurons in the barrel cortex.
dc.contributor.author | Popescu, Ion R. | |
dc.contributor.author | Le Kathy, Q. | |
dc.contributor.author | Palenzuela Muñoz, Rocío | |
dc.contributor.author | Voglewede, Rebecca | |
dc.contributor.author | Mostany, Ricardo | |
dc.date.accessioned | 2018-02-01T12:32:43Z | |
dc.date.available | 2018-02-01T12:32:43Z | |
dc.date.issued | 2017 | |
dc.description.abstract | Pyramidal neuron subtypes differ in intrinsic electrophysiology properties and dendritic morphology. However, do different pyramidal neuron subtypes also receive synaptic inputs that are dissimilar in frequency and in excitation/inhibition balance? Unsupervised clustering of three intrinsic parameters that vary by cell subtype – the slow afterhyperpolarization, the sag, and the spike frequency adaptation – split layer 5 barrel cortex pyramidal neurons into two clusters: one of adapting cells and one of non-adapting cells, corresponding to previously described thin- and thick-tufted pyramidal neurons, respectively. Non-adapting neurons presented frequencies of spontaneous inhibitory postsynaptic currents (sIPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) three- and two-fold higher, respectively, than those of adapting neurons. The IPSC difference between pyramidal subtypes was activity independent. A subset of neurons were thy1-GFP positive, presented characteristics of non-adapting pyramidal neurons, and also had higher IPSC and EPSC frequencies than adapting neurons. The sEPSC/sIPSC frequency ratio was higher in adapting than in non-adapting cells, suggesting a higher excitatory drive in adapting neurons. Therefore, our study on spontaneous synaptic inputs suggests a different extent of synaptic information processing in adapting and non-adapting barrel cortex neurons, and that eventual deficits in inhibition may have differential effects on the excitation/inhibition balance in adapting and non-adapting neurons. | spa |
dc.description.extent | 3365 KB | spa |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10641/1384 | |
dc.language.iso | eng | spa |
dc.publisher | Nature Scientific Reports | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.title | Marked bias towards spontaneous synaptic inhibition distinguishes non-adapting from adapting layer 5 pyramidal neurons in the barrel cortex. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | SMUR | spa |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 5a1ac1af-4ed8-49a7-bd0f-5afd5cc1e97c | |
relation.isAuthorOfPublication.latestForDiscovery | 5a1ac1af-4ed8-49a7-bd0f-5afd5cc1e97c |
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