Vaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and Omicron.

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dc.contributor.authorMartínez-González, Brenda
dc.contributor.authorRuiz Hornillos, Francisco Javier
dc.contributor.authorPerales, Celia
dc.date.accessioned2023-02-27T12:28:03Z
dc.date.available2023-02-27T12:28:03Z
dc.date.issued2022
dc.description.abstractReplication of SARS-CoV-2 in the human population is defined by distributions of mutants that are present at different frequencies within the infected host and can be detected by ultra-deep sequencing techniques. In this study, we examined the SARS-CoV-2 mutant spectra of amplicons from the spike-coding (S-coding) region of 5 nasopharyngeal isolates derived from patients with vaccine breakthrough. Interestingly, all patients became infected with the Alpha variant, but amino acid substitutions that correspond to the Delta Plus, Iota, and Omicron variants were present in the mutant spectra of the resident virus. Deep sequencing analysis of SARS-CoV-2 from patients with vaccine breakthrough revealed a rich reservoir of mutant types and may also identify tolerated substitutions that can be represented in epidemiologically dominant variants.spa
dc.description.extent656 KBspa
dc.identifier.doi10.1172/JCI157700spa
dc.identifier.issn0021-9738spa
dc.identifier.urihttps://hdl.handle.net/10641/3278
dc.language.isoengspa
dc.publisherJournal of Clinical Investigationspa
dc.relation.publisherversionhttps://www.jci.org/articles/view/157700spa
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessspa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.titleVaccine breakthrough infections with SARS-CoV-2 Alpha mirror mutations in Delta Plus, Iota, and Omicron.spa
dc.typejournal articlespa
dc.type.hasVersionAMspa
dspace.entity.typePublication

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