New Insights in the Involvement of the Endocannabinoid System and Natural Cannabinoids in Nicotine Dependence.
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2021
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International Journal of Molecular Sciences
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Abstract
Nicotine, the main psychoactive component in tobacco smoke, plays a major role in
tobacco addiction, producing a high morbidity and mortality in the world. A great amount of
research has been developed to elucidate the neural pathways and neurotransmitter systems
involved in such a complex addictive behavior. The endocannabinoid system, which has been
reported to participate in the addictive properties of most of the prototypical drugs of abuse, is also
implicated in nicotine dependence. This review summarizes and updates the main behavioral and
biochemical data involving the endocannabinoid system in the rewarding properties of nicotine as
well as in nicotine withdrawal and relapse to nicotine‐seeking behavior. Promising results from
preclinical studies suggest that manipulation of the endocannabinoid system could be a potential
therapeutic strategy for treating nicotine addiction.
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Nicotine, Cannabinoid, Withdrawal, Anandamide, 2‐ arachidonoylglycerol