FACULTAD DE CIENCIAS EXPERIMENTALES

Permanent URI for this collectionhttps://hdl.handle.net/10641/5228

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Effects of Cognitive Training on Balance and Motor Symptoms in Parkinson's Disease : An Exploratory Randomized Controlled Trial
(2025-05-01) Arroyo-Ferrer, Aída; Moreno-Verdú, Marcos; Sánchez-Cuesta, Francisco José; González-Zamorano, Yeray; Ugalde-Canitrot, Arturo; Romero, Juan Pablo; Neurorrehabilitación del daño cerebral y los trastornos del movimiento (GINDAT); Facultad de Ciencias Experimentales; Facultad de Medicina
Industrial-produced lemon nanovesicles ameliorate experimental colitis-associated damages in rats via the activation of anti-inflammatory and antioxidant responses and microbiota modification
(2024-05) Tinnirello, Vincenza; Zizzo, Maria Grazia; Conigliaro, Alice; Tabone, Mariangela; Ganji, Nima Rabienezhad; Cicio, Adele; Bressa, Carlo; Larrosa, Mar; Rappa, Francesca; Vergilio, Giuseppe; Gasparro, Roberta; Gallo, Alessia; Serio, Rosa Maria; Alessandro, Riccardo; Raimondo, Stefania; Facultad de Ciencias Experimentales
Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft-versus-host disease
(2024-06-03) Moe, Alison; Rayasam, Aditya; Sauber, Garrett; Shah, Ravi K.; Doherty, Ashley; Yuan, Cheng Yin; Szabo, Aniko; Moore, Bob M.; Colonna, Marco; Cui, Weiguo; Romero, Julian; Zamora, Anthony E.; Hillard, Cecilia J.; Drobyski, William R.; Facultad de Ciencias Experimentales
Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely understood. Using a murine model of GVHD, we demonstrate that type 2 cannabinoid receptor (CB2R) signaling plays a critical role in the pathophysiology of neuroinflammation. In these studies, we identify that CB2R expression on microglial cells induces an activated inflammatory phenotype that potentiates the accumulation of donor-derived proinflammatory T cells, regulates chemokine gene regulatory networks, and promotes neuronal cell death. Pharmacological targeting of this receptor with a brain penetrant CB2R inverse agonist/antagonist selectively reduces neuroinflammation without deleteriously affecting systemic GVHD severity. Thus, these findings delineate a therapeutically targetable neuroinflammatory pathway and have implications for the attenuation of neurotoxicity after GVHD and potentially other T cell–based immunotherapeutic approaches.
The Impact of A3AR Antagonism on the Differential Expression of Chemoresistance-Related Genes in Glioblastoma Stem-like Cells
(2024-05) Peñate, Liuba; Carrillo-Beltrán, Diego; Spichiger, Carlos; Cuevas-Zhbankova, Alexei; Torres-Arévalo, Ángelo; Silva, Pamela; Richter, Hans G.; Ayuso-Sacido, Ángel; San Martín, Rody; Quezada-Monrás, Claudia; Facultad de Ciencias Experimentales
The Peptidoglycan Recognition Protein 1 confers immune evasive properties on pancreatic cancer stem cells
(2024-08-08) Lopez-Gil, Juan Carlos; Garcia-Silva, Susana; Ruiz-Cañas, Laura; Navarro, Diego; Palencia-Campos, Adrian; Giraldez-Trujillo, Antonio; Earl, Julie; Dorado, Jorge; Gomez-Lopez, Gonzalo; Monfort-Vengut, Ana; Alcala, Sonia; Gaida, Matthias M.; Garcia-Mulero, Sandra; Cabezas-Sainz, Pablo; Batres-Ramos, Sandra; Barreto, Emma; Sanchez-Tomero, Patricia; Vallespinos, Mireia; Ambler, Leah; Lin, Meng Lay; Aicher, Alexandra; Garcia Garcia De Paredes, Ana; De La Pinta, Carolina; Sanjuanbenito, Alfonso; Ruz-Caracuel, Ignacio; Rodriguez-Garrote, Mercedes; Guerra, Carmen; Carrato, Alfredo; De Carcer, Guillermo; Sanchez, Laura; Nombela-Arrieta, Cesar; Espinet, Elisa; Sanchez-Arevalo Lobo, Victor Javier; Heeschen, Christopher; Sainz, Bruno; Facultad de Ciencias Experimentales
Synthetically derived BiAux modulates auxin co-receptor activity to stimulate lateral root formation
(2024-06) González-García, Mary Paz; Sáez, Angela; Lanza, Mónica; Hoyos, Pilar; Bustillo-Avendaño, Estefano; Pacios, Luis F.; Gradillas, Ana; Moreno-Risueno, Miguel A.; Hernaiz, María José; del Pozo, Juan C.; Facultad de Ciencias Experimentales
Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion
(2024-07) Portela-Lomba, María; Simón, Diana; Callejo-Móstoles, Marta; de la Fuente, Gemma; Fernández de Sevilla, David; García-Escudero, Vega; Moreno-Flores, M. Teresa; Sierra, Javier; Facultad de Ciencias Experimentales; Facultad de Medicina
Proteomic profiles of peritoneal fluid-derived small extracellular vesicles correlate with patient outcome in ovarian cancer
(2024-05-15) Quiralte, Miguel; Barquín, Arantzazu; Yagüe-Fernández, Mónica; Navarro, Paloma; Grazioso, Tatiana P.; Sevillano-Fernández, Elena; Rodriguez-Moreno, Juan F.; Balarezo-Saldivar, Alejandra; Peinado, Héctor; Izquierdo, Elena; Millán, Carlos; López-Carrasco, Irene; Prieto, Mario; Madurga, Rodrigo; Fernández-Miranda, Ismael; Ruiz-Llorente, Sergio; García-Donas, Jesús; Facultad de Ciencias Experimentales
The association of circulating bioenergetic metabolites with healthy human aging
(2024-09) Navas-Enamorado, C.; Capo, X.; Galmes-Panades, A. M.; Ortega-Moral, A.; Sánchez-Polo, A.; Masmiquel, L.; Torrens-Mas, M.; Navas, P.; Gonzalez-Freire, M.; Facultad de Ciencias Experimentales
Cluster/shell citrate-Fe3O4/chitosan nanoparticles for enhancing heating efficiency in combined magnetic and photothermal therapy
(2024-10-01) García-García, Gracia; Lázaro, Marina; Cenalmor, Alejandro; García-Álvarez, Isabel; Iglesias, Guillermo R.; Arias, José L.; Facultad de Ciencias Experimentales
Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance
(2024-07) Guenther, Kelsey G.; Lin, Xiaoyan; Xu, Zhili; Makriyannis, Alexandros; Romero, Julian; Hillard, Cecilia J.; Mackie, Ken; Hohmann, Andrea G.; Facultad de Ciencias Experimentales
Red blood cell flickering activity locally controlled by holographic optical tweezers
(2024-06-21) Caselli, Niccolò; García-Verdugo, Mario; Calero, Macarena; Hernando-Ospina, Natalia; Santiago, José A.; Herráez-Aguilar, Diego; Monroy, Francisco; Facultad de Ciencias Experimentales
Circulating Levels of Leptin in Different Phases of the Menstrual Cycle. A Systematic Review and Meta-Analysis.
(Elsevier, 2024) Panchawagh, Suhrud J.; Kumar, Pratyush; Srikumar, Shabarini; Prajapati, Khushi; Sarkar, Manali; Abhishek, Kumar; Agrawal, Poonam; Kaushal, G. P.; García-Martínez, Daniel J.; Kalra, Swati; Bhutia, Euden; Agarwal, Aman; Singh, Kunika; Sharma, Shubhangi; Ashok, Tejaswini; Shah, Urmil; Shukla, Rushikesh; Gupta, Sejal; Shaikh, Hareem; Soumya, K. Sri; S. S, Poorvikha
Role of Micronutrients in the Management of Autism Spectrum Disorders: : A Systematic Review and Meta‐Analysis
(2023-10) Panchawagh, Suhrud J.; Kumar, Pratyush; Srikumar, Shabarini; Sarkar, Manali; Ashok, Tejaswini; Gupta, Sejal; Shaikh, Hareem; Soumya, K. Sri; S, Poorvikha S; Abhishek, Kumar; Agrawal, Poonam; Kaushal, G. P.; Shah, Urmil; Shukla, Rushikesh; García-Martínez, Daniel J.; Prajapati, Khushi; Agarwal, Aman; Singh, Kunika; Sharma, Shubhangi; Facultad de Ciencias Experimentales
Impact of emerging COVID-19 variants on psychosocial health : A systematic review
(2025-02-01) Kumar, Pratyush; Sarkar, Manali; Morales Femenias, Yurkina; García-Martínez, Daniel J.; Gnanaraj, Ramya; Pisfil‐Farroñay, Yhojar A.; Chaudhary, Laxmi; Agrawal, Poonam; Kaushal, G. P.; Mbwogge9, Mathew; Abhishek, Kumar; Alnaasan, Muhannad; Arlettaz, Maximiliano Ezequiel; Kozum, Reem; Júarez M, Miguel F.; Panchawagh, Suhrud; P. Reddy, Asmitha; Unnithan, Vishnu B.; Shukla, Rushikesh; Facultad de Ciencias Experimentales
The COVID-19 pandemic has had significant psychological effects on individuals and communities around the world. Studies have found that the prevalence of anxiety and depression symptoms increased significantly during the pandemic. The goal of the study is to understand how the emerging new virus variants keep the world in a state of fear and how mental health measures can be implemented and adopted to alleviate anxiety. A broad search for observational studies was carried out in Pubmed, Google Scholar, Clinical Key, and World Medical Library. Studies that reported and/or related the existence of anxiety generated by suffering or not from diseases caused by the new emerging COVID-19 viruses and that for which the full text of the article was accessible were included in the study, while systematic review and meta-analysis and studies in groups were excluded. However, 22 studies were included in the review. The deleterious psychosocial effects were the restructuring of life, establishment of unhealthy habits, emergence of “corona phobia”, fear and stigma of being afflicted with the disease and spreading it to loved ones, and lack of contact with others. Increased rates of depression and anxiety were also seen. The circulating variants responsible for these main psychosocial repercussions were Epsilon, Zeta, Eta, Iota, Kappa, Alpha, Beta, Gamma, and Delta. Social support was found to be protective. There is a critical need for a comprehensive approach addressing not only the physiological well-being of an individual but also their mental well-being to pave the way for a society that is resilient in the face of current as well as future pandemics.
Transcranial Direct Current Stimulation as Adjuvant to Gamified Rehabilitation for Upper Limb Function in Paediatric Brain Damage (CHILDBOOST Project) : A Study Protocol for a Triple-Blind Randomised Controlled Trial
(2024-08) Cerezo-Zarzuelo, Almudena; Rios-Lago, Marcos; Sanchez-Cuesta, Francisco Jose; Gavilan-Agusti, Beatriz; Romero, Juan Pablo; Facultad de Ciencias Experimentales
Pushing the Limits of Lateral Flow Immunoassay by Digital SERS for the Ultralow Detection of SARS-CoV-2 Virus
(2024-11) González-Cabaleiro, Lara; Fernández-Lodeiro, Carlos; Vázquez-Iglesias, Lorena; Soriano-Maldonado, Pablo; van Raaij, Mark J.; Bodelón, Gustavo; Pérez-Juste, Jorge; Pastoriza-Santos, Isabel; Facultad de Ciencias Experimentales
Metabolic-Associated Fatty Liver Disease and Cognitive Performance in Type 2 Diabetes : Basal Data from the Phytate, Neurodegeneration and Diabetes (PHYND) Study
(2024-09) Pujol, Antelm; Sanchis, Pilar; Tamayo, María I.; Godoy, Samantha; Calvó, Paula; Olmos, Asier; Andrés, Pilar; Speranskaya, Aleksandra; Espino, Ana; Estremera, Ana; Rigo, Elena; Amengual, Guillermo J.; Rodríguez, Manuel; Ribes, José Luis; Gomila, Isabel; Grases, Félix; González-Freire, Marta; Masmiquel, Lluís; Facultad de Ciencias Experimentales
Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships : Insights from Roche’s Endocannabinoid System Projects
(2024) Aebi, Johannes; Atz, Kenneth; Ametamey, Simon M.; Benz, Jörg; Blaising, Julie; Butini, Stefania; Campiani, Giuseppe; Carreira, Erick M.; Collin, Ludovic; de Lago, Eva; Gazzi, Thais; Gertsch, Jürg; Gobbi, Luca; Guba, Wolfgang; Fernández-Ruiz, Javier; Fingerle, Jürgen; Haider, Ahmed; He, Yingfang; Heitman, Laura H.; Honer, Michael; Hunziker, Daniel; Kuhn, Bernd; Maccarrone, Mauro; Märki, Hans Peter; Martin, Rainer E.; Mohr, Peter; Mu, Linjing; Nazaré, Marc; Nippa, David F.; Oddi, Sergio; O’Hara, Fionn; Pacher, Pal; Romero, Julian; Röver, Stephan; Rufer, Arne C.; Schibli, Roger; Schneider, Gisbert; Stepan, Antonia F.; Sykes, David A.; Ullmer, Christoph; van der Stelt, Mario; Veprintsev, Dmitry B.; Wittwer, Matthias B.; Grether, Uwe; Facultad de Ciencias Experimentales
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating key functions within the central nervous and immune systems. Given its therapeutic significance, we have launched a series of drug discovery endeavors aimed at ECS targets, including peroxisome proliferator-activated receptors (PPARs), cannabinoid receptors types 1 (CB1R) and 2 (CB2R), and monoacylglycerol lipase (MAGL), addressing a wide array of medical needs. The pursuit of new therapeutic agents has been enhanced by the creation of specialized labeled chemical probes, which aid in target localization, mechanistic studies, assay development, and the establishment of biomarkers for target engagement. By fusing medicinal chemistry with chemical biology in a comprehensive, translational end-to-end drug discovery strategy, we have expedited the development of novel therapeutics. Additionally, this strategy promises to foster highly productive partnerships between industry and academia, as will be illustrated through various examples.
Circulating endocannabinoid levels in SARS-CoV-2 infection and their potential role in the inflammatory response
(2024-12) Velasco, Maria; Posada-Ayala, Maria; Pérez-Fernández, Elia; Loria, Frida; Amores, Mario; Ramos, José Miguel; Jaime, Elena; Guijarro, Carlos; Romero, Julián; Pazos, Maria Ruth; Facultad de Ciencias Experimentales; Facultad de Medicina

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