NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-kB Activation.
dc.contributor.author | Tesoro Santos, Laura | |
dc.contributor.author | Hernández, Ignacio | |
dc.contributor.author | Ramírez Carracedo, Rafael | |
dc.contributor.author | Díez-Mata, Javier | |
dc.contributor.author | Alcharani, Nunzio | |
dc.contributor.author | Jiménez-Guirado, Beatriz | |
dc.contributor.author | Ovejero-Paredes, Karina | |
dc.contributor.author | Filice, Marco | |
dc.contributor.author | Zamorano, Jose Luis | |
dc.contributor.author | Saura, Marta | |
dc.contributor.author | Zaragoza Sánchez, Carlos | |
dc.contributor.author | Botana, Laura | |
dc.date.accessioned | 2022-12-12T13:02:32Z | |
dc.date.available | 2022-12-12T13:02:32Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Background: Early response after acute myocardial infarction (AMI) prevents extensive cardiac necrosis, in which inflammation resolution, including expression of anti-inflammatory interleukin-10 (IL-10), may play a key role. (2) Methods: We synthesized NIL10, a micelle-based nanoparticle, to target IL-10 receptor in mice and pigs subjected to AMI. (3) Results: Administration of NIL10 induced cardiac protection of wild-type and IL-10 knockout mice and pigs subjected to AMI. Cardiac protection was not induced in IL-10-receptor null mice, as shown by a significant recovery of cardiac function, in which inflammatory foci and fibrosis were strongly reduced, together with the finding that resolving M2-like macrophage populations were increased after day 3 of reperfusion. In addition, anti-inflammatory cytokines, including IL-4, IL-7, IL-10, IL-13, IL-16, and IL-27 were also elevated. Mechanistically, NIL10 induced activation of the IL-10 receptor/STAT-3 signaling pathway, and STAT3-dependent inhibition of nuclear translocation of pro-inflammatory NF-kB transcription factor. (4) Conclusions: Taken together, we propose using NIL10 as a novel therapeutic tool against AMI-induced cardiac damage | spa |
dc.description.extent | 4711 KB | spa |
dc.identifier.doi | 10.3390/pharmaceutics14102044 | spa |
dc.identifier.issn | 1999-4923 | spa |
dc.identifier.uri | https://hdl.handle.net/10641/3190 | |
dc.language.iso | eng | spa |
dc.publisher | Pharmaceutics | spa |
dc.relation.publisherversion | https://www.mdpi.com/1999-4923/14/10/2044 | spa |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | spa |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Acute myocardial infarction | spa |
dc.subject | Interleukin-10 | spa |
dc.subject | Nanoparticles | spa |
dc.title | NIL10: A New IL10-Receptor Binding Nanoparticle That Induces Cardiac Protection in Mice and Pigs Subjected to Acute Myocardial Infarction through STAT3/NF-kB Activation. | spa |
dc.type | journal article | spa |
dc.type.hasVersion | AM | spa |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | f739a89c-f1cb-4d99-a0e8-560a8b063182 | |
relation.isAuthorOfPublication | a1854c1f-1c01-4cee-a866-fd372311dc18 | |
relation.isAuthorOfPublication | 4827c8bf-8195-470b-b931-e6f378643b1e | |
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relation.isAuthorOfPublication | d8b48195-2b61-490d-8a8f-69b4079a6847 | |
relation.isAuthorOfPublication.latestForDiscovery | f739a89c-f1cb-4d99-a0e8-560a8b063182 |
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