Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.

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URI: http://hdl.handle.net/10641/3092
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2022.01.009

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2022

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Highlights • Administration of BML-111, a stable LXA4 analog, protects against cardiac dysfunction by avoiding Ca2+ mishandling induced by autoimmune myocarditis in a mouse model. • Beneficial effects of the SPMs on intracellular Ca2+ handling are mainly caused by a regulation of SERCA2A by NRF2. • Cardiac tissue obtained from individuals diagnosed with myocarditis, compared with healthy myocardium tissues, displayed depressed mRNA levels of ATP2A2 (SERCA2A) and NF2L2 (NRF2).

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Calcium handling, Myocarditis, Pro-resolving mediators

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FACULTAD DE MEDICINA