Dichotomous colorectal cancer behaviour.
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2023
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Critical Reviews in Oncology/Hematology
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Abstract
Colorectal cancer (CRC) is the third most common malignant tumor and one of the deadliest cancers. At molecular
level, CRC is a heterogeneous disease that could be divided in four Consensus Molecular Subtypes. Given
the differences in the disease due to its anatomical location (proximal and distal colon), another classification
should be considered. Here, we review the current knowledge on CRC dichotomic´s behaviour based on two
different entities; right and left-sided tumors, their impact on clinical trial data, microbiota spatial composition
and the interaction with the nervous system. We discuss recent advances in understanding how the spatial tumor
heterogeneity influences the tumor growth, progression, and responses to current therapies
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Keywords
Colorectal cancer, Right side, Left side, Microbiota, Clinical trials